Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction).

Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction). Research Abstract Details 

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Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction). Abstract Text:

Gangguo Zhu,Ei-ichi Negishi,

The ZACA reaction has been shown to proceed satisfactorily with internally OH-substituted 1-alkenes, provided that the OH group is unprotected and non-allylic. This reaction was used for reagent-controlled asymmetric construction of 3. Allylic alcohol was converted to 2 in seven steps via iterative ZACA processes and simple chromatography. (-)-Spongidepsin (1) was synthesized by using 2 and 3 through application of the esterification-amidation-ring-closing metathesis protocol previously reported.

Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction). Publishing Authors By Initials

G Zhu,E Negishi,

For similar inorganic chemicals: elements: metals, heavy: zirconium research abstracts see: inorganic chemicals: elements: metals, heavy: zirconium research

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Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction). Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Organic letters

VOLUME: 9

Page Numbers: 2771-4

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 21

MONTH: 06

YEAR: 2007

Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction). Information

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LANGUAGE: eng

NlmUniqueID: 100890393

Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction). Keywords Mesh Terms:

KEYWORDS: Zirconium

MESH TERMS: chemistry

Chemical & Substance for Abstract: Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction). Information

Substance Name: Zirconium

Registry Number: 7440-67-7

Grant and Affiliation Information for Fully reagent-controlled asymmetric synthesis of (-)-spongidepsin via the Zr-catalyzed asymmetric carboalumination of alkenes (ZACA reaction).

AFFILIATION: Herbert C. Brown Laboratories of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, Indiana 47907-2084, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 36792

ACRONYM: GM

MEDLINETA: Org Lett

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