Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.

Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. Research Abstract Details 

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Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. Abstract Text:

Brent H Koehn,Matthew A Williams,Keshawna Borom,Shivaprakash Gangappa,Thomas C Pearson,Rafi Ahmed,Christian P Larsen,

The establishment of mixed allogeneic chimerism can induce donor-specific transplantation tolerance across full MHC barriers. However, a theoretical disadvantage of this approach is the possibility that the state of mixed chimerism might negatively affect the recipient's immune competence to control pathogens. Previous studies using murine models have not supported this hypothesis, because they indicate that acute viral infections are cleared by chimeric animals with similar kinetics to that of unmanipulated controls. However, chronic or persistent viral infections often require a more complex and sustained response with cooperation between CD4 Th cells, CTL, and B cells for effective control. The current study indicates that profound defects become manifest in the control of chronic pathogenic infections in MHC-disparate mixed allogeneic chimeric mice. Furthermore, we show that ineffective priming of the donor-restricted CTL response leads to virus persistence, as well as severe T cell exhaustion. Our results further suggest that either T cell adoptive immunotherapy or selected MHC haplotype matching partially restore immune competence. These approaches may facilitate the translation of mixed chimerism therapeutic regimens.

Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. Publishing Authors By Initials

BH Koehn,MA Williams,K Borom,S Gangappa,TC Pearson,R Ahmed,CP Larsen,

For similar surgical procedures, operative: transplantation: transplantation, homologous research abstracts see: surgical procedures, operative: transplantation: transplantation, homologous research

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Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of immunology (Baltimore, Md. : 1950)

VOLUME: 179

Page Numbers: 2616-26

Journal Abbreviation: J. Immunol.

ISSN: 0022-1767

DAY: 15

MONTH: Aug

YEAR: 2007

Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. Information

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LANGUAGE: eng

NlmUniqueID: 2985117

Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. Keywords Mesh Terms:

KEYWORDS: Transplantation, Homologous

MESH TERMS: immunology

Chemical & Substance for Abstract: Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections. Information

Substance Name: Histocompatibility Antigens

Registry Number: 0

Grant and Affiliation Information for Fully MHC-disparate mixed hemopoietic chimeras show specific defects in the control of chronic viral infections.

AFFILIATION: Emory Transplant Center and Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI44644

ACRONYM: AI

MEDLINETA: J Immunol

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