FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor.

FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor. Research Abstract Details 

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FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor. Abstract Text:

Y Li,S Ganta,C Cheng,R Craig,R R Ganta,L C Freeman,

A number of FSH receptor (FSH-R) isoforms with distinct structural motifs and signaling paradigms have been described, including a single transmembrane domain variant that functions as a growth factor type receptor (FSH-R3). This study tested the hypothesis that FSH can stimulate ovarian cancer cell proliferation by acting on FSH-R3, using the tumorigenic mouse ovarian surface epithelial cell (MOSEC) line ID8. FSH enhanced ID8 proliferation in a concentration-dependent fashion. Moreover, FSH-treatment of ID8 elicited intracellular events consistent with activation of FSH-R3 and distinct from those associated with activation of the canonical G-protein coupled FSH-R isoform (FSH-R1). Specifically, the FSH-R3 signaling pathway included cAMP-independent activation of ERK downstream of an SNX-482 sensitive component likely to be the Cav2.3 calcium channel. Northern analysis using probes specific for exons 7 and 11 of FSH-R identified consistently only one 1.9kb transcript. Immunoblot analysis confirmed expression of FSH-R3 but not FSHR-1 in ID8. Together, these data suggest that FSH-R3 signaling promotes proliferation of ovarian cancer cells.

FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor. Publishing Authors By Initials

Y Li,S Ganta,C Cheng,R Craig,RR Ganta,LC Freeman,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

PUBMED ID PMID:

MEDLINE DATE:

FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular and cellular endocrinology

VOLUME: 267

Page Numbers: 26-37

Journal Abbreviation: Mol. Cell. Endocrinol.

ISSN: 0303-7207

DAY: 16

MONTH: 01

YEAR: 2007

FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7500844

FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: drug effects

Chemical & Substance for Abstract: FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor. Information

Substance Name: Extracellular Signal-Regulated MAP Kinas

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for FSH stimulates ovarian cancer cell growth by action on growth factor variant receptor.

AFFILIATION: Department of Anatomy & Physiology, Kansas State University, Manhattan, KS 66506, USA.

Country: Ireland

AGENCY: United States NICHD

GRANT: R01-HD-36002

ACRONYM: HD

MEDLINETA: Mol Cell Endocrinol

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