Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Research Abstract Details 

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Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Abstract Text:

Laura G ,Edilia Tapia,Adriana ,Pablo Bautista,Magdalena , Nepomuceno,Virgilia Soto,Carmen Avila-Casado,Takahiko Nakagawa,Richard J Johnson,Jaime Herrera-Acosta,Martha Franco,

Fructose intake has been recently linked to the epidemic of metabolic syndrome and, in turn, the metabolic syndrome has been epidemiologically linked with renal progression. The renal hemodynamic effects of fructose intake are unknown, as well as the effects of different routes of administration. Metabolic syndrome was induced in rats over 8 wk by either a high-fructose diet (60%, F60, n = 7) or by adding fructose to drinking water (10%, F10, n = 7). Body weight and food and fluid intake of each rat were measured weekly during the follow-up. At baseline and at the end of wk 8, systolic blood pressure, plasma uric acid, and triglycerides were measured. At the end of week 8 glomerular hemodynamics was evaluated by micropuncture techniques. Wall thickening in outer cortical and juxtamedullary afferent arterioles was assessed by immunohistochemistry and computer image analysis. Fructose administration either in diet or drinking water induced hypertension, hyperuricemia, and hypertriglyceridemia; however, there was a progressive increment in these parameters with higher fructose intake (C

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Publishing Authors By Initials

LG ,E Tapia,A ,P Bautista,M ,T Nepomuceno,V Soto,C Avila-Casado,T Nakagawa,RJ Johnson,J Herrera-Acosta,M Franco,

For similar heterocyclic compounds: alkaloids: xanthines: uric acid research abstracts see: heterocyclic compounds: alkaloids: xanthines: uric acid research

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Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F423-9

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 29

MONTH: 08

YEAR: 2006

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Information

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LANGUAGE: eng

NlmUniqueID: 100901990

Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Keywords Mesh Terms:

KEYWORDS: Uric Acid

MESH TERMS: metabolism

Chemical & Substance for Abstract: Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Information

Substance Name: Uric Acid

Registry Number: 69-93-2

Grant and Affiliation Information for Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats.

AFFILIATION: Dept. of Nephrology, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1. 14080, Mexico City, Mexico. lgsanchezlozada@hotmail.com

Country: United States

AGENCY: United States NHLBI

GRANT: HL-68607

ACRONYM: HL

MEDLINETA: Am J Physiol Renal Physiol

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