Frontostriatal dysfunction during response inhibition in Williams syndrome.

Frontostriatal dysfunction during response inhibition in Williams syndrome. Research Abstract Details 

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Frontostriatal dysfunction during response inhibition in Williams syndrome. Abstract Text:

Dean Mobbs,Mark A Eckert,Debra Mills,Julie Korenberg,Ursula Bellugi,Albert M Galaburda,Allan L Reiss,

BACKGROUND: Williams syndrome (WS) has provided researchers with an exciting opportunity to understand the complex interplay among genes, neurobiological and cognitive functions. However, despite a well-characterized cognitive and behavioral phenotype, little attention has been paid to the marked deficits in social and behavioral inhibition. Here we explore the neural systems that mediate response inhibition in WS. METHODS: We used functional MRI (fMRI) to obtain blood oxygenation level dependence (BOLD) signal maps during the performance of a Go/NoGo response inhibition task from 11 clinically and genetically diagnosed WS patients and 11 age- and gender-matched typically developing (TD) control subjects. Correlations between behavioral, neuropsychological measures, and BOLD signal were also conducted. RESULTS: Although TD control subjects showed significantly faster response times, no group differences in behavioral accuracy were observed. Compared with control subjects, WS participants demonstrated significantly reduced activity in the striatum, dorsolateral prefrontal, and dorsal anterior cingulate cortices. These findings support the hypothesis that persons with WS fail to activate critical cortical and subcortical structures involved in behavioral inhibition. CONCLUSIONS: Our results provide important evidence for reduced engagement of the frontostriatal circuits in WS and provide putative biological markers for the deficits in response inhibition and the unusual social phenotype.

Frontostriatal dysfunction during response inhibition in Williams syndrome. Publishing Authors By Initials

D Mobbs,MA Eckert,D Mills,J Korenberg,U Bellugi,AM Galaburda,AL Reiss,

For similar nervous system diseases: neurologic manifestations: neurobehavioral manifestations: mental retardation: williams syndrome research abstracts see: nervous system diseases: neurologic manifestations: neurobehavioral manifestations: mental retardation: williams syndrome research

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Frontostriatal dysfunction during response inhibition in Williams syndrome. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biological psychiatry

VOLUME: 62

Page Numbers: 256-61

Journal Abbreviation: Biol. Psychiatry

ISSN: 0006-3223

DAY: 25

MONTH: 09

YEAR: 2006

Frontostriatal dysfunction during response inhibition in Williams syndrome. Information

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LANGUAGE: eng

NlmUniqueID: 213264

Frontostriatal dysfunction during response inhibition in Williams syndrome. Keywords Mesh Terms:

KEYWORDS: Williams Syndrome

MESH TERMS: physiopathology

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Grant and Affiliation Information for Frontostriatal dysfunction during response inhibition in Williams syndrome.

AFFILIATION: Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305-5719, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH50047

ACRONYM: MH

MEDLINETA: Biol Psychiatry

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