Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder.

Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Research Abstract Details 

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Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Abstract Text:

E S Monkul,J P Hatch,M A Nicoletti,S Spence,P Brambilla,A L T Lacerda,R B Sassi,A G Mallinger,M S Keshavan,J C Soares,

Our knowledge about the neurobiology of suicide is limited. It has been proposed that suicidal behavior generally requires biological abnormalities concomitant with the personality trait of impulsivity/aggression, besides an acute psychiatric illness or psychosocial stressor. We investigated fronto-limbic anatomical brain abnormalities in suicidal and non-suicidal adult female patients with unipolar depression. Our sample consisted of seven suicidal unipolar patients, 10 non-suicidal unipolar patients and 17 healthy female comparison subjects. The criterion for suicidality was one or more documented lifetime suicide attempts. A 1.5T GE Signa Imaging System running version Signa 5.4.3 software was used to acquire the magnetic resonance imaging images. All anatomical structures were measured blindly, with the subjects' identities and group assignments masked. We used analysis of covariance with age and intracranial volume as covariates and the Tukey-Kramer procedure to compare suicidal patients, non-suicidal patients and healthy comparison subjects. Suicidal patients had smaller right and left orbitofrontal cortex gray matter volumes compared with healthy comparison subjects. Suicidal patients had larger right amygdala volumes than non-suicidal patients. Abnormalities in the orbitofrontal cortex and amygdala in suicidal patients may impair decision-making and predispose these patients to act more impulsively and to attempt suicide.

Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Publishing Authors By Initials

ES Monkul,JP Hatch,MA Nicoletti,S Spence,P Brambilla,AL Lacerda,RB Sassi,AG Mallinger,MS Keshavan,JC Soares,

For similar behavior and behavior mechanisms: behavior: behavioral symptoms: self-injurious behavior: suicide research abstracts see: behavior and behavior mechanisms: behavior: behavioral symptoms: self-injurious behavior: suicide research

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Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Molecular psychiatry

VOLUME: 12

Page Numbers: 360-6

Journal Abbreviation: Mol. Psychiatry

ISSN: 1359-4184

DAY: 5

MONTH: 12

YEAR: 2006

Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Information

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LANGUAGE: eng

NlmUniqueID: 9607835

Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder. Keywords Mesh Terms:

KEYWORDS: Suicide

MESH TERMS: methods

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Grant and Affiliation Information for Fronto-limbic brain structures in suicidal and non-suicidal female patients with major depressive disorder.

AFFILIATION: MOOD-CNS Program (Mood Disorders Clinical Neurosciences Program), Department of Psychiatry, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.

Country: England

AGENCY: United States NCRR

GRANT: RR020571

ACRONYM: RR

MEDLINETA: Mol Psychiatry

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