Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis.

Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Research Abstract Details 

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Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Abstract Text:

Dustin Y Yoon,Colin D Gause,James F Leckman,Harvey S Singer,

Frontal-subcortical abnormalities have been implicated in the pathophysiology of Tourette syndrome (TS). The goal of this study was to more extensively evaluate a possible underlying neurochemical abnormality in frontal cortex. Postmortem brain tissue from frontal and occipital regions (Brodmann's areas 4, 6, 9, 10, 11, 12, and 17) from three TS patients and three age-and sex-matched controls were analyzed by semiquantitative immunoblotting. Relative densities were measured for a variety of neurochemical markers including dopamine (D1, D2), serotonin (5HT-1A), and alpha-adrenergic (alpha-2A) receptors, the dopamine transporter (DAT), a monoamine terminal marker (vesicular monoamine transporter type 2, VMAT-2), and vesicular docking and release proteins (VAMP-2, synaptotagmin, SNAP-25, syntaxin, synaptophysin). Data from each TS sample, corrected for actin content, was expressed as a percentage value of its control. Results identified consistent increases of DAT and D2 receptor density in five of six frontal regions in all three TS subjects. D1 and alpha-2A receptor density were increased in a few frontal regions. These results support the hypothesis of a dopaminergic dysfunction in the frontal lobe and a likely role in the pathophysiology of TS.

Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Publishing Authors By Initials

DY Yoon,CD Gause,JF Leckman,HS Singer,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the neurological sciences

VOLUME: 255

Page Numbers: 50-6

Journal Abbreviation: J. Neurol. Sci.

ISSN: 0022-510X

DAY: 6

MONTH: 03

YEAR: 2007

Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375403

Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: physiology

Chemical & Substance for Abstract: Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis. Information

Substance Name: Dopamine

Registry Number: 51-61-6

Grant and Affiliation Information for Frontal dopaminergic abnormality in Tourette syndrome: a postmortem analysis.

AFFILIATION: Department of Neurology, Johns Hopkins University School of Medicine, Harriett Lane Outpatient Building, 200 N. Wolfe Street, Suite 2158, Baltimore, MD 21205, USA.

Country: Netherlands

AGENCY: United States NIMH

GRANT: P01MH049351

ACRONYM: MH

MEDLINETA: J Neurol Sci

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