From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy.

From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy. Research Abstract Details 

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From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy. Abstract Text:

Dongsheng Duan,

The gene encoding dystrophin, which is altered in Duchenne muscular dystrophy, is one of the largest in mammalian species. Adeno-associated virus (AAV) is the smallest viral gene delivery vector with a "cargo" capacity of 6 kb and is the most effective gene delivery vehicle to muscle cells. Overlapping and trans-splicing AAV vector approaches are devised to do the "impossible."

From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy. Publishing Authors By Initials

D Duan,

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From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Discovery medicine

VOLUME: 6

Page Numbers: 103-8

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ISSN: 1539-6509

DAY: 19

MONTH: Jun

YEAR: 2006

From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy. Information

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LANGUAGE: eng

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Grant and Affiliation Information for From the smallest virus to the biggest gene: marching towards gene therapy for duchenne muscular dystrophy.

AFFILIATION: Department of Molecular Microbiology and Immunology, The University of Missouri School of Medicine, One Hospital Drive, Columbia, MO 65212, USA.

Country: United States

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MEDLINETA: Discov Med

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