From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on {beta}-arrestin-2 interactions in vivo.

From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on {beta}-arrestin-2 interactions in vivo. Research Abstract Details 

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From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on {beta}-arrestin-2 interactions in vivo. Abstract Text:

Cullen L Schmid,Kirsten M Raehal,Laura M Bohn,Cullen L Schmid,Kirsten M Raehal,Laura M Bohn,Cullen L Schmid,Kirsten M Raehal,Laura M Bohn,

Visual and auditory hallucinations accompany certain neuropsychiatric disorders, such as schizophrenia, and they also can be induced by the use or abuse of certain drugs. The heptahelical serotonin 2A receptors (5-HT2ARs) are molecular targets for drug-induced hallucinations. However, the cellular mechanisms by which the 5-HT2AR mediates these effects are not well understood. Drugs acting at the 5-HT2AR can trigger diverse signaling pathways that may be directed by the chemical properties of the drug. beta-arrestins are intracellular proteins that bind to heptahelical receptors and represent a point where such divergences in ligand-directed functional signaling could occur. Here we compare the endogenous agonist, serotonin, to a synthetic 5-HT2AR hallucinogenic agonist, 2,5-dimethoxy-4-iodoamphetamine (DOI), in mice lacking beta-arrestin-2, as well as in cells lacking beta-arrestins. In mice, we find that serotonin induces a head twitch response by a beta-arrestin-2-dependent mechanism. However, DOI invokes the behavior independent of beta-arrestin-2. The two structurally distinct agonists elicit different signal transduction and trafficking patterns upon activation of 5-HT2AR, which hinge on the presence of beta-arrestins. Our study suggests that the 5-HT2AR-beta-arrestin interaction may be particularly important in receptor function in response to endogenous serotonin levels, which could have major implications in drug development for treating neuropsychiatric disorders such as depression and schizophrenia.

From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on {beta}-arrestin-2 interactions in vivo. Publishing Authors By Initials

CL Schmid,KM Raehal,LM Bohn,CL Schmid,KM Raehal,LM Bohn,CL Schmid,KM Raehal,LM Bohn,

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From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on {beta}-arrestin-2 interactions in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 1079-84

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 14

MONTH: 01

YEAR: 2008

From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on {beta}-arrestin-2 interactions in vivo. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for From the Cover: Agonist-directed signaling of the serotonin 2A receptor depends on {beta}-arrestin-2 interactions in vivo.

AFFILIATION: Departments of Pharmacology and Psychiatry, Ohio State University College of Medicine, Columbus, OH 43210.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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