From T-cell activation signals to signaling control of anti-cancer immunity.

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From T-cell activation signals to signaling control of anti-cancer immunity. Abstract Text:

Shane J F Cronin,Josef M Penninger,Shane J F Cronin,Josef M Penninger,Shane J F Cronin,Josef M Penninger,

The activation of resting T cells is crucial to most immune processes. Recognition of foreign antigen by T-cell receptors has to be correctly translated into signal transduction events necessary for the induction of an effective immune response. In this review, we discuss the essential signals, molecules, and processes necessary to achieve full T-cell activation. In addition to describing these key biological events, we also discuss how T-cell receptor signaling may be harnessed to yield new therapeutic targets for a next generation of anti-cancer drugs.

From T-cell activation signals to signaling control of anti-cancer immunity. Publishing Authors By Initials

SJ Cronin,JM Penninger,SJ Cronin,JM Penninger,SJ Cronin,JM Penninger,

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From T-cell activation signals to signaling control of anti-cancer immunity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Immunological reviews

VOLUME: 220

Page Numbers: 151-68

Journal Abbreviation: Immunol. Rev.

ISSN: 0105-2896

DAY: 5

MONTH: Dec

YEAR: 2007

From T-cell activation signals to signaling control of anti-cancer immunity. Information

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LANGUAGE: eng

NlmUniqueID: 7702118

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AFFILIATION: IMBA, Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, Austria.

Country: Denmark

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MEDLINETA: Immunol Rev

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