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From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation.

From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation. Research Abstract Details 

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  • From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation. Abstract Text:

    inderpal singh kocharInderpal Singh Kochar,khalid hussainKhalid Hussain,

    INTRODUCTION: Newborns with intrauterine growth retardation (IUGR) have multiple risk factors for developing hypoglycaemia. Hyperinsulinism, both transient and prolonged, is one of the major risk factors responsible for the hypoglycaemia observed in some newborns with IUGR. Once the child has progressed beyond the infancy period, the most common cause of hypoglycaemia is ketotic hypoglycaemia. We report our observations of ketotic hypoglycaemia in six children who were born with IUGR and developed hyperinsulinaemic hypoglycaemia (HH) that required treatment with diazoxide and chlorothiazide. RESULTS: In one of these children the ketotic hypoglycaemia was found to be due to growth hormone deficiency; in the remaining five patients, however, no cause for the hypoglycaemia could be found, despite extensive investigations. These observations suggest that ketotic hypoglycaemia may be more common in children with a history of IUGR. Further studies are required to understand why some newborns with IUGR and HH have an increased risk of ketotic hypoglycaemia in childhood. CONCLUSION: Newborns with a history of IUGR and HH have an increased risk of developing ketotic hypoglycaemia in the childhood period.

    From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation. Publishing Authors By Initials

    is kocharIS Kochar,k hussainK Hussain,

    For similar abstracts research abstracts see: abstracts research

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    From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation. Journal Published:

    PUBLICATION TYPE: Journal Article

    Journal: European journal of pediatrics

    VOLUME: 166

    Page Numbers: 1003-7

    Journal Abbreviation: Eur. J. Pediatr.

    ISSN: 0340-6199

    DAY: 20

    MONTH: 12

    YEAR: 2006

    From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation. Information

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    LANGUAGE: eng

    NlmUniqueID: 7603873

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    Grant and Affiliation Information for From hyperinsulinaemic hypoglycaemia to ketotic hypoglycaemia: the range of glucose abnormalities in patients born with intrauterine growth retardation.

    AFFILIATION: London Centre for Paediatric Endocrinology and Metabolism, Great Ormond Street Hospital for Children NHS Trust, London, WC1N 3JH, UK.

    Country: Germany

    Germany Research PublicationGermany Research Publication

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    MEDLINETA: Eur J Pediatr

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