Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis.

Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Research Abstract Details 

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Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Abstract Text:

Luciano Potena,Cecile T J Holweg,Marcy L Vana,Leena Bashyam,Jaya Rajamani,A Louise McCormick,John P Cooke,Hannah A Valantine,Edward S Mocarski,

Despite antiviral prophylaxis, a high percentage (over 90%) of heart transplant patients experience active cytomegalovirus (CMV) infection, diagnosed by detection of viral DNA in peripheral blood polymorphonuclear leukocytes within the first few months posttransplantation. Viral DNA was detected in mononuclear cells prior to detection in granulocytes from CMV-seropositive recipients (R+) receiving a heart from a CMV-seropositive donor (D+). Based on assessment of systemic infection in leukocyte populations, both R+ subgroups (R+/D- and R+/D+) experienced a greater infection burden than the R-/D+ subgroup, which was aggressively treated because of a higher risk of acute CMV disease. Despite widespread systemic infection in all at-risk patient subgroups, CMV DNA was rarely (< 3% of patients) detected in transplanted heart biopsy specimens. The R+ patients more frequently exceeded the 75th percentile of the CMV DNA copy number distribution in leukocytes (110 copies/10(5) polymorphonuclear leukocytes) than the R-/D+ subgroup. Therefore, active systemic CMV infection involving leukocytes is common in heart transplant recipients receiving prophylaxis to reduce acute disease. Infection of the transplanted organ is rare, suggesting that chronic vascular disease attributed to CMV may be driven by the consequences of systemic infection.

Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Publishing Authors By Initials

L Potena,CT Holweg,ML Vana,L Bashyam,J Rajamani,AL McCormick,JP Cooke,HA Valantine,ES Mocarski,

For similar virus diseases: viremia research abstracts see: virus diseases: viremia research

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Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of clinical microbiology

VOLUME: 45

Page Numbers: 1804-10

Journal Abbreviation: J. Clin. Microbiol.

ISSN: 0095-1137

DAY: 4

MONTH: 04

YEAR: 2007

Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505564

Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Keywords Mesh Terms:

KEYWORDS: Viremia

MESH TERMS: virology

Chemical & Substance for Abstract: Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Information

Substance Name: Ganciclovir

Registry Number: 82410-32-0

Grant and Affiliation Information for Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis.

AFFILIATION: Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

Country: United States

AGENCY: United States NIAID

GRANT: P01 AI50153

ACRONYM: AI

MEDLINETA: J Clin Microbiol

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