[Frequency of pregnant HBsAg carriers in a Brazilian community]

[Frequency of pregnant HBsAg carriers in a Brazilian community] Research Abstract Details 

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[Frequency of pregnant HBsAg carriers in a Brazilian community] Abstract Text:

G Duarte,M M Mussi-Pinhata,R Martinez,C Lemos,E M Leite Figueiredo,S M Quintana,

In view of the benefits of immunoprophylaxis among newborns of mothers who are seropositive for hepatitis B virus (HBV) surface antigen (HBsAG), these women must be correctly identified so that this measure can be instituted in Brazil. The research reported here studied 7992 women who gave birth in the Hospital das Clínicas of the Ribeirão Preto School of Medicine, University of São Paulo (HCFMRP-USP), Brazil, in order to determine the rate of serum reactivity of HBsAg and other markers of HBV infection among these women, and also to evaluate the risk factors for this infection. Serum reactivity for HBsAg was determined by means of an immunoenzymatic test (ELISA) carried out in two stages: the first with an incubation period of 2 hours (screening), and the second with an incubation period of 18 hours (confirmation) for those samples that were positive in the screening test. The markers anti-HBsAg, HBeAg, anti-HBcAg, and anti-HBeAG were tested in the samples that were confirmed positive. The screening test found 1.05% (95% CI: 0.84 - 1.30) of the samples to be positive for HBsAg. However, only 0.95% (95% CI: 0.75 - 1.19) were confirmed positive, the percentage being significantly higher among patients whose pregnancies had ended in abortion (1.84%) than among those who had given birth (0.84%) (X2, Yates correction = 7.76; P < 0.005). Risk factors for HBV infection could be identified for only 27.6% of the study subjects, based on their recall and reporting. Of the women with confirmed positive samples, 21.3% also were positive for HBeAG, indicating that these patients ran a greater risk of transmitting the virus vertically. These results underline the need for specific serologic studies in the final stage of pregnancy in order to offer the maximum benefit of neonatal immunoprophylaxis.

[Frequency of pregnant HBsAg carriers in a Brazilian community] Publishing Authors By Initials

G Duarte,MM Mussi-Pinhata,R Martinez,C Lemos,EM Leite Figueiredo,SM Quintana,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: seroepidemiologic studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: seroepidemiologic studies research

PUBMED ID PMID:

MEDLINE DATE:

[Frequency of pregnant HBsAg carriers in a Brazilian community] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Boletín de la Oficina Sanitaria Panamericana. Pan

VOLUME: 120

Page Numbers: 189-97

Journal Abbreviation:

ISSN: 0030-0632

DAY: 28

MONTH: Mar

YEAR: 1996

[Frequency of pregnant HBsAg carriers in a Brazilian community] Information

Number of References:

LANGUAGE: por

NlmUniqueID: 414762

[Frequency of pregnant HBsAg carriers in a Brazilian community] Keywords Mesh Terms:

KEYWORDS: Seroepidemiologic Studies

MESH TERMS: blood

Chemical & Substance for Abstract: [Frequency of pregnant HBsAg carriers in a Brazilian community] Information

Substance Name: Hepatitis B Surface Antigens

Registry Number: 0

Grant and Affiliation Information for [Frequency of pregnant HBsAg carriers in a Brazilian community]

AFFILIATION: Hospital das Clínicas de Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.

Country: UNITED STATES

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ACRONYM:

MEDLINETA: Bol Oficina Sanit Panam

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