Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis.

Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Abstract Text:

PURPOSE: To evaluate the human leucocyte antigen (HLA) class 1 (HLA-A and HLA-B) and HLA class 2 (HLA-DRB1 and HLA-DQB1) allele profiles in the susceptibility to cytomegalovirus retinitis (CMV-R) in patients with AIDS. METHODS: Cytomegalovirus retinitis was clinically diagnosed by indirect binocular ophthalmoscopy. Human leucocyte antigens class 1 were typed using a complement-dependent microlymphocytotoxicity assay, and HLA class 2 alleles were identified using amplified DNA hybridized to sequence-specific oligonucleotide primers. RESULTS: The frequencies of HLA class 1 antigens and HLA class 2 alleles observed in patients and controls were similar; however, HLA-A31 antigen was over-represented in patients with AIDS, independent of the presence of CMV-R. CONCLUSION: There was no association between HLA molecules/alleles and CMV-R in Brazilian patients with AIDS. However, the results support the role of the HLA system in the susceptibility to developing AIDS.

Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Publishing Authors By Initials

For similar persons: age groups: adult: middle aged research abstracts see: persons: age groups: adult: middle aged research

PUBMED ID PMID:

MEDLINE DATE:

Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta ophthalmologica Scandinavica

VOLUME: 81

Page Numbers: 514-6

Journal Abbreviation: Acta Ophthalmol Scand

ISSN: 1395-3907

DAY: 17

MONTH: Oct

YEAR: 2003

Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9507578

Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Keywords Mesh Terms:

KEYWORDS: Middle Aged

MESH TERMS: genetics

Chemical & Substance for Abstract: Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis. Information

Substance Name: Histocompatibility Antigens Class II

Registry Number: 0

Grant and Affiliation Information for Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis.

AFFILIATION: Faculty of Medicine of Ribeirão Preto, Ophthalmology 12 andar, Campus USP, University of São Paulo, 14048-900 Ribeirão Preto, São Paulo, Brazil. mdlvrodr@fmrp.usp.br

Country: Denmark

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Acta Ophthalmol Scand

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis Related Publications

• A majority of Brazilian patients with rheumatoid arthritis HLA-DRB1 alleles carry both the HLA-DRB1 shared epitope and anti-citrunillated peptide antibodies.
• A novel HLA-G allele, HLA-G*010111, in the Brazilian population.
• A pilot case-control association study of cytokine polymorphisms in Brazilian women presenting with HPV-related cervical lesions.
• Absence of the HLA-G*0105N allele in Amerindian populations from the Brazilian Amazon Region: a possible role of natural selection.
• Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil.
• CCR5-Delta32 genetic polymorphism associated with benign clinical course and magnetic resonance imaging findings in Brazilian patients with multiple sclerosis.
• Efficiency of the DNA repair and polymorphisms of the XRCC1, XRCC3 and XRCC4 DNA repair genes in systemic lupus erythematosus.
• Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis.
• Frequency of insertion/deletion polymorphism in exon 8 of HLA-G and kidney allograft outcome.
• HLA Polymorphisms as Incidence Factor in the Progression to End-Stage Renal Disease in Brazilian Patients Awaiting Kidney Transplant.
• HLA-G polymorphism and transitional cell carcinoma of the bladder in a Brazilian population.
• Human leukocyte antigen-G expression after kidney transplantation is associated with a reduced incidence of rejection.
• TNF Microsatellite Alleles in Brazilian Chagasic Patients.
• The role of major histocompatibility complex alleles in the susceptibility of Brazilian patients to develop the myogenic type of Graves' orbitopathy.