Frequency of high-risk use of QT-prolonging medications.

Frequency of high-risk use of QT-prolonging medications. Research Abstract Details 

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Frequency of high-risk use of QT-prolonging medications. Abstract Text:

Nancy M Allen LaPointe,Lesley H Curtis,K Arnold Chan,Judith M Kramer,Jennifer Elston Lafata,Jerry H Gurwitz,Marsha A Raebel,Richard Platt,

PURPOSE: Prolongation of the QT interval has been associated with increased risk of torsades de pointes and death. Concurrent use of more than one QT-prolonging drug or a QT-prolonging drug with a drug that alters its pharmacokinetic profile is an important risk factor for adverse outcomes. METHODS: Using a representative sample of 2 million health plan members from 10 health maintenance organizations with pharmacy benefits between January 1999 and July 2001, we identified potential drug interactions involving QT-prolonging medications. Prescription claims overlapping by at least 7 days for either 2 or more QT-prolonging drugs or a QT-prolonging drug with a drug that alters its clearance were considered potential drug interactions. We determined the number of drug interactions overall and the number of these interactions involving patients with other risk factors for torsades de pointes. RESULTS: A total of 48 465 potential drug interactions were identified in 10 415 (4.6%) of the 228 550 patients with at least one prescription for a QT-prolonging drug. Amitriptyline was involved in 37 859 (78.1%) of the drug interactions. Of all potential drug interactions, 43 689 (90.1%) occurred in patients with at least one other risk factor for torsades de pointes, and 1053 (2.2%) were listed as a contraindicated combination in product labeling. CONCLUSION: Potential drug interactions involving currently marketed QT-prolonging drugs occurred in 4.6% of patients who had a prescription for a QT-prolonging medication. The findings suggest several areas for targeted interventions to decrease the potential risk from QT-prolonging medications.

Frequency of high-risk use of QT-prolonging medications. Publishing Authors By Initials

NM Allen LaPointe,LH Curtis,KA Chan,JM Kramer,JE Lafata,JH Gurwitz,MA Raebel,R Platt,

For similar cardiovascular diseases: heart diseases: arrhythmias, cardiac: tachycardia: tachycardia, ventricular: torsades de pointes research abstracts see: cardiovascular diseases: heart diseases: arrhythmias, cardiac: tachycardia: tachycardia, ventricular: torsades de pointes research

PUBMED ID PMID:

MEDLINE DATE:

Frequency of high-risk use of QT-prolonging medications. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Pharmacoepidemiology and drug safety

VOLUME: 15

Page Numbers: 361-8

Journal Abbreviation:

ISSN: 1053-8569

DAY: 3

MONTH: Jun

YEAR: 2006

Frequency of high-risk use of QT-prolonging medications. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9208369

Frequency of high-risk use of QT-prolonging medications. Keywords Mesh Terms:

KEYWORDS: Torsades de Pointes

MESH TERMS: chemically induced

Chemical & Substance for Abstract: Frequency of high-risk use of QT-prolonging medications. Information

Substance Name: Amitriptyline

Registry Number: 50-48-6

Grant and Affiliation Information for Frequency of high-risk use of QT-prolonging medications.

AFFILIATION: Duke Center for Education and Research on Therapeutics, Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27715, USA. allen003@mc.duke.edu

Country: England

AGENCY: United States AHRQ

GRANT: U18 HS010548

ACRONYM: HS

MEDLINETA: Pharmacoepidemiol Drug Saf

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