Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis.

Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis. Abstract Text:

Takefumi Matsuo,Hiroko Kobayashi,Miyako Matsuo,Keiko Wanaka,Hidetomo Nakamoto,Hiroyuki Matsushima,Rumi Sakai,Takefumi Matsuo,Hiroko Kobayashi,Miyako Matsuo,Keiko Wanaka,Hidetomo Nakamoto,Hiroyuki Matsushima,Rumi Sakai,

The aim of this study was to determine the frequency of heparin/platelet factor (PF) 4 complex antibodies in 305 uremic patients treated with chronic intermittent hemodialysis using unfractionated heparin or low-molecular-weight heparin for 3 months. Heparin-induced thrombocytopenia (HIT) antibodies were detected by ELISA in 7 patients (2.3%) who had no history of HIT. Two patients abruptly developed HIT associated with the formation of clots in the extracorporeal circuit after they were found to be carrying HIT antibodies. These patients were suspected to have a similar trigger: an increased dose of recombinant human erythropoietin (rHuEPO). The drug might induce parallel changes in hematocrit (Ht) levels and platelet counts until the onset of HIT. After the onset of HIT, a parallel phenomenon between Ht and platelet counts was not found because of the thrombocytopenia due to HIT. Although HIT onset has been reported during the initial phase of dialysis sessions, there have been few reports on the onset of HIT in uremic patients on dialysis with long-term heparin anticoagulation. In this study, HIT was observed in 2 uremic patients on chronic dialysis with intermittent use of heparin. In some patients on chronic intermittent dialysis carrying HIT antibodies, HIT may occur following rHuEPO treatment. The presence of HIT should be borne in mind in chronic dialysis patients carrying HIT antibodies for 3 months or more.

Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis. Publishing Authors By Initials

T Matsuo,H Kobayashi,M Matsuo,K Wanaka,H Nakamoto,H Matsushima,R Sakai,T Matsuo,H Kobayashi,M Matsuo,K Wanaka,H Nakamoto,H Matsushima,R Sakai,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pathophysiology of haemostasis and thrombosis

VOLUME: 35

Page Numbers: 445-50

Journal Abbreviation: Pathophysiol. Haemost. Thromb.

ISSN: 1424-8832

DAY: 13

MONTH: 06

YEAR: 2006

Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101142710

Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis.

AFFILIATION: Hyogo Prefectural Awaji Hospital, Sumoto, Japan. matsuo-t@awaji-hosp.sumoto.hyogo.jp

Country: Switzerland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pathophysiol Haemost Thromb

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Frequency of anti-heparin-PF4 complex antibodies HIT antibodies in uremic patients on chronic intermittent hemodialysis Related Publications

• A New Indole Alkaloid, 7 alpha-Hydroxy-7H-mitragynine, from Mitragyna speciosa in Thailand.
• A method for removing copper from charcoal of waste wood using an electrical current.
• A rare case of invasive ductal carcinoma with hyperprolactinemia.
• Actin filament organization of foot processes in vertebrate glomerular podocytes.
• Arteriovenous malformation in association with moyamoya disease. Report of two cases.
• Bifunctional enzyme fusion of 3-hexulose-6-phosphate synthase and 6-phospho-3-hexuloisomerase.
• Correlation of hepatic steatosis with body mass index, serum ferritin level and hepatic fibrosis in Japanese patients with chronic hepatitis C.
• Determination of four metabolites of dothiepin in urine by high-performance liquid chromatography.
• Double-balloon enteroscopy in the diagnosis of an adenocarcinoma of the fourth portion of the duodenum: report of a case.
• Dynamic body weight and body composition changes in response to subordination stress.
• EUS-guided FNA facilitates the diagnosis of retroperitoneal endometriosis.
• Effects of fibrillin-1 degradation on microfibril ultrastructure.
• Epidermal hyperplasia and papillomatosis in mice with a keratinocyte-restricted deletion of csk.
• Epithelioid vascular leiomyoma of the uterus mimicking glomangiomyoma.
• Esophagojejunostomy through minilaparotomy after laparoscopic total gastrectomy.
• Fragmentation of Protein Kinase N (PKN) in the Hydrocephalic Rat Brain.
• Frequency of anti-heparin-PF4 complex antibodies (HIT antibodies) in uremic patients on chronic intermittent hemodialysis.
• Glycosylation modulates TRAIL-R1/death receptor 4 protein: different regulations of two pro-apoptotic receptors for TRAIL by tunicamycin.
• Hepatic iron accumulation may be associated with insulin resistance in patients with chronic hepatitis C.
• Historical evolution of anatomical terminology from ancient to modern.
• Identification of JTP-70902, a p15(INK4b)-inductive compound, as a novel MEK1/2 inhibitor.
• Mechanical components of rat intestinal villi as revealed by ultrastructural analysis with special reference to the axial smooth muscle cells in the villi.
• Parasporin-2Ab, a newly isolated cytotoxic crystal protein from Bacillus thuringiensis.
• Preparation of tiny biodegradable capsules using electrocapillary emulsification.
• Repeat operations in the management of clival chordomas: palliative surgery.
• Richter and sodium appetite: from adrenalectomy to molecular biology.
• Significance of alpha-smooth muscle actin expression in IgA nephropathy: Revisited.
• Strengthening emergency obstetric care in Nepal: The Women's Right to Life and Health Project (WRLHP).
• The C-terminus of ephrin-B1 regulates metalloproteinase secretion and invasion of cancer cells.
• [Technological study of image quality in PET examination using commercial FDG delivery]