Frequency and outcome of cervical cancer prevention failures in the United States.

Frequency and outcome of cervical cancer prevention failures in the United States. Research Abstract Details 

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Frequency and outcome of cervical cancer prevention failures in the United States. Abstract Text:

Stephen S Raab,Dana Marie Grzybicki,Richard J Zarbo,Chris Jensen,Stanley J Geyer,Janine E Janosky,Frederick A Meier,Colleen M Vrbin,Gloria Carter,Kim R Geisinger,

We measured the frequency and outcome of cervical cancer prevention failures that occurred in the Papanicolaou (Pap) and colposcopy testing phases involving 1,646,580 Pap tests in 4 American hospital systems between January 1, 1998, and December 31, 2004. We defined a screening failure as a 2-step or greater discordant Pap test result and follow-up biopsy diagnosis. A total of 5,278 failures were detected (0.321% of all Pap tests); 48% and 52% of failures occurred in the Pap test and colposcopy phases, respectively. Missed squamous cancers (1 in 187,786 Pap tests), glandular cancers (1 in 19,426 Pap tests), and high-grade lesions (1 in 6,870 Pap tests) constituted 4.1% of all failures. Unnecessary repeated tests or diagnostic delays occurred in 70.8% and 63.9% of failures involving high- and low-grade lesions, respectively. We conclude that cervical cancer prevention practices are remarkably successful in preventing squamous cancers, although a high frequency of failures results in low-impact negative outcomes.

Frequency and outcome of cervical cancer prevention failures in the United States. Publishing Authors By Initials

SS Raab,DM Grzybicki,RJ Zarbo,C Jensen,SJ Geyer,JE Janosky,FA Meier,CM Vrbin,G Carter,KR Geisinger,

For similar diagnosis: diagnostic techniques and procedures: diagnostic techniques, obstetrical and gynecological: vaginal smears research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic techniques, obstetrical and gynecological: vaginal smears research

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Frequency and outcome of cervical cancer prevention failures in the United States. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of clinical pathology

VOLUME: 128

Page Numbers: 817-24

Journal Abbreviation: Am. J. Clin. Pathol.

ISSN: 0002-9173

DAY: 29

MONTH: Nov

YEAR: 2007

Frequency and outcome of cervical cancer prevention failures in the United States. Information

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LANGUAGE: eng

NlmUniqueID: 370470

Frequency and outcome of cervical cancer prevention failures in the United States. Keywords Mesh Terms:

KEYWORDS: Vaginal Smears

MESH TERMS: statistics & numerical data

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Grant and Affiliation Information for Frequency and outcome of cervical cancer prevention failures in the United States.

AFFILIATION: Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, and Western Pennsylvania Hospital 15232, USA.

Country: United States

AGENCY: United States PHS

GRANT: HJS13321-01

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MEDLINETA: Am J Clin Pathol

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