Freeze casting of porous hydroxyapatite scaffolds. I. Processing and general microstructure.

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Freeze casting of porous hydroxyapatite scaffolds. I. Processing and general microstructure. Abstract Text:

Freeze casting of aqueous suspensions on a cold substrate was investigated as a method for preparing hydroxyapatite (HA) scaffolds with unidirectional porosity. In the present paper, we report on the ability to manipulate the microstructure of freeze-cast constructs by controlling the processing parameters. Constructs prepared from aqueous suspensions (5-20 volume percent particles) on a steel substrate at -20 degrees C had a lamellar-type microstructure, consisting of plate-like HA and unidirectional pores oriented in the direction of freezing. Sintering for 3 h at 1350 degrees C produced constructs with dense HA lamellas, porosity of approximately 50%, and inter-lamellar pore widths of 5-30 mum. The thickness of the HA lamellas decreased but the width of the pores increased with decreasing particle concentration. Decreasing the substrate temperature from -20 degrees C to -196 degrees C produced a finer lamellar microstructure. The use of water-glycerol mixtures (20 wt % glycerol) as the solvent in the suspension resulted in the production of finer pores (1-10 mum) and a larger number of dendritic growth connecting the HA lamellas. On the other hand, the use of water-dioxane mixtures (60 wt % dioxane) produced a cellular-type microstructure with larger pores (90-110 mum). The ability to produce a uniaxial microstructure and its manipulation by controlling the processing parameters indicate the potential of the present freeze casting route for the production of scaffolds for bone tissue engineering applications. (c) 2007 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2008.

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Freeze casting of porous hydroxyapatite scaffolds. I. Processing and general microstructure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomedical materials research. Part B,

VOLUME: 86

Page Numbers: 125-35

Journal Abbreviation: J. Biomed. Mater. Res. Part B

ISSN: 1552-4981

DAY: 23

MONTH: Jul

YEAR: 2008

Freeze casting of porous hydroxyapatite scaffolds. I. Processing and general microstructure. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Freeze casting of porous hydroxyapatite scaffolds. I. Processing and general microstructure.

AFFILIATION: Department of Materials Science and Engineering, University of Missouri-Rolla, Rolla, Missouri 65409.

Country: United States

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MEDLINETA: J Biomed Mater Res B Appl Biom

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