Fragile X syndrome: assessment and treatment implications.

Fragile X syndrome: assessment and treatment implications. Research Abstract Details 

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Fragile X syndrome: assessment and treatment implications. Abstract Text:

Allan L Reiss,Scott S Hall,

Fragile X syndrome (FraX) is the most common known cause of inherited mental impairment. FMR1 gene mutations, the cause of FraX, lead to reduced expression of FMR1 protein and an increased risk for a particular profile of cognitive, behavioral, and emotional dysfunction. The study of individuals with FraX provides a unique window of understanding into important disorders such as autism, social phobia, cognitive disability, and depression. This review highlights the typical phenotypic features of individuals with FraX, discussing the apparent strengths and weaknesses in intellectual functioning, as evidenced from longitudinal follow-up studies. It also discusses recent neuroanatomic findings that may pave the way for more focused disease-specific pharmacologic and behavioral interventions. This article describes the results of recent medication trials designed to target symptoms associated with FraX. It also describes some recent behavioral interventions that were conducted in our laboratory.

Fragile X syndrome: assessment and treatment implications. Publishing Authors By Initials

AL Reiss,SS Hall,

For similar nervous system diseases: neurologic manifestations: neurobehavioral manifestations: mental retardation research abstracts see: nervous system diseases: neurologic manifestations: neurobehavioral manifestations: mental retardation research

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MEDLINE DATE:

Fragile X syndrome: assessment and treatment implications. Journal Published:

PUBLICATION TYPE: Review

Journal: Child and adolescent psychiatric clinics of North

VOLUME: 16

Page Numbers: 663-75

Journal Abbreviation:

ISSN: 1056-4993

DAY: 3

MONTH: Jul

YEAR: 2007

Fragile X syndrome: assessment and treatment implications. Information

Number of References: 85

LANGUAGE: eng

NlmUniqueID: 9313451

Fragile X syndrome: assessment and treatment implications. Keywords Mesh Terms:

KEYWORDS: Mental Retardation

MESH TERMS: genetics

Chemical & Substance for Abstract: Fragile X syndrome: assessment and treatment implications. Information

Substance Name: Fragile X Mental Retardation Protein

Registry Number: 139135-51-6

Grant and Affiliation Information for Fragile X syndrome: assessment and treatment implications.

AFFILIATION: Center for Interdisciplinary Brain Sciences Research, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305-5975, USA.

Country: United States

AGENCY: United States NIMH

GRANT: MH64708

ACRONYM: MH

MEDLINETA: Child Adolesc Psychiatr Clin N

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