Fracture healing in the elderly patient.

Fracture healing in the elderly patient. Research Abstract Details 

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Fracture healing in the elderly patient. Abstract Text:

Reinhard Gruber, Koch,Bruce A Doll,Florian Tegtmeier,Thomas A Einhorn,Jeffrey O Hollinger,

Clinical experience gives rise to the impression that there are differences in fracture healing in different age groups. It is evident that fractures heal more efficiently in children than in adults. However, minimal objective knowledge exists to evaluate this assumption. Temporal, spatial, and cellular quantitative and qualitative interrelationships, as well as signaling molecules and extracellular matrix have not been comprehensively and adequately elucidated for fracture healing in the geriatric skeleton. The biological basis of fracture healing will provide a context for revealing the pathophysiology of delayed or even impaired bone regeneration in the elderly. We will summarize experimental studies on age-related changes at the cellular and molecular level that will add to the pathophysiological understanding of the compromised bone regeneration capacity believed to exist in the elderly patient. We will suggest why this understanding would be useful for therapeutics focused on bone regeneration, in particular fracture healing at an advanced age.

Fracture healing in the elderly patient. Publishing Authors By Initials

R Gruber,H Koch,BA Doll,F Tegtmeier,TA Einhorn,JO Hollinger,

For similar genetic phenomena: phenotype research abstracts see: genetic phenomena: phenotype research

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Fracture healing in the elderly patient. Journal Published:

PUBLICATION TYPE: Review

Journal: Experimental gerontology

VOLUME: 41

Page Numbers: 1080-93

Journal Abbreviation: Exp. Gerontol.

ISSN: 0531-5565

DAY: 7

MONTH: 11

YEAR: 2006

Fracture healing in the elderly patient. Information

Number of References: 171

LANGUAGE: eng

NlmUniqueID: 47061

Fracture healing in the elderly patient. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Fracture healing in the elderly patient. Information

Substance Name: Bone Morphogenetic Proteins

Registry Number: 0

Grant and Affiliation Information for Fracture healing in the elderly patient.

AFFILIATION: Department of Oral Surgery, Medical University of Vienna, Austria.

Country: England

AGENCY: United States NIDCR

GRANT: R01-DE13018-02

ACRONYM: DE

MEDLINETA: Exp Gerontol

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