Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice.

Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Abstract Text:

Dong-Jin Oh,Belda Dursun,Zhibin He,Lawrence Lu,Thomas S Hoke,Danica Ljubanovic,Sarah Faubel,Charles L Edelstein,Dong-Jin Oh,Belda Dursun,Zhibin He,Lawrence Lu,Thomas S Hoke,Danica Ljubanovic,Sarah Faubel,Charles L Edelstein,

Fractalkine (CX3CL1) is expressed on injured endothelial cells and is a potent chemoattractant and adhesion molecule for macrophages carrying the fractalkine receptor (CX3CR1). The aim of this study was to investigate the role of CX3CL1, and its ligand CX3CR1, in ischemic acute renal failure (ARF) in mice. On immunoblotting, CX3CL1 protein expression in the kidney increased markedly in ischemic ARF. On immunofluorescence staining, the intensity of CX3CL1 staining in blood vessels was significantly more prominent in ischemic ARF compared with controls. A specific anti-CX3CR1 antibody (25 mug ip 1 h before induction of ischemia) was functionally and histologically protective against ischemic ARF. CX3CR1 is predominantly expressed on macrophages. Macrophage infiltration in the kidney in ischemic ARF was significantly decreased after anti-CX3CR1 antibody treatment. To determine the role of macrophages in ischemic ARF, macrophages in the kidney were depleted using liposomal-encapsulated clodronate (LEC). LEC resulted in significant functional and histological protection against ischemic ARF. In summary, in ischemic ARF, 1) there is upregulation of CX3CL1 protein in the kidney, specifically in blood vessels; 2) CX3CR1 inhibition using a specific antibody is partially protective and is associated with reduced macrophage infiltration in the kidney; and 3) macrophage depletion in the kidney is protective.

Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Publishing Authors By Initials

DJ Oh,B Dursun,Z He,L Lu,TS Hoke,D Ljubanovic,S Faubel,CL Edelstein,DJ Oh,B Dursun,Z He,L Lu,TS Hoke,D Ljubanovic,S Faubel,CL Edelstein,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of physiology. Renal physiology

VOLUME: 294

Page Numbers: F264-71

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 14

MONTH: 11

YEAR: 2007

Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901990

Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice.

AFFILIATION: Univ. of Colorado Health Sciences Center, Div. of Renal Diseases and Hypertension, Box C281, 4200 E 9th Ave., Denver, Colorado 80262. Charles.Edelstein@UCHSC.edu).

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Physiol Renal Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Fractalkine receptor CX3CR1 inhibition is protective against ischemic acute renal failure in mice Related Publications

• A brief survey of 25 cases of tick-borne relapsing fever.
• A prospective study of dehydroepiandrosterone sulfate and cognitive function in an older population: the Rancho Bernardo Study.
• Acute kidney injury complicating minimal change disease: the case for careful use of diuretics and angiotensin-converting enzyme inhibitors.
• Biochemical and biomechanical properties of avian callus after local administration of dihydroxylated vitamin D metabolites.
• COMPARATIVE EFFECTS OF CURRENT TOPICAL CORTICOSTEROIDS.
• Candida parapsilosis septic arthritis in a renal transplant patient.
• Caspase-3 gene deletion prolongs survival in polycystic kidney disease.
• Cisplatin-induced acute renal failure is associated with an increase in the cytokines interleukin (IL)-1beta, IL-18, IL-6, and neutrophil infiltration in the kidney.
• Convergent In Vivo and In Vitro Selection of Ceftazidime Resistance Mutations at Position 167 of CTX-M-3 {beta}-Lactamase in Hypermutable Escherichia coli Strains.
• Culture diagnosis of Legionella infections.
• Effect of statin and angiotensin-converting enzyme inhibition on structural and hemodynamic alterations in autosomal dominant polycystic kidney disease model.
• Fractalkine receptor (CX3CR1) inhibition is protective against ischemic acute renal failure in mice.
• Impact of desire to work in underserved communities on selection of specialty among fourth-year medical students.
• In memoriam of Professor J. M. Edelstein Johannesburg.
• Increased macrophage infiltration and fractalkine expression in cisplatin-induced acute renal failure in mice.
• Intradermal hyaluronidase corticosteroid therapy.
• Joseph Melvin Edelstein, 1896-1966.
• Letter: Banded structure in cellular blue nevus.
• Levels of active metabolites of vitamin D3 in the callus of fracture repair in chicks.
• Magnetic resonance without nuclei?
• Magnetic resonance without nuclei?
• Plantar verruca and immunity.
• Pressure ulcer success story.
• Rapid diagnosis of Legionnaires' disease.
• The development of orthopedic surgery in South Africa during the past half-century.
• Therapeutic interventions for autosomal dominant polycystic kidney disease.
• Tips and taboos in the treatment of allergic dermatoses.
• VEGF receptor inhibition slows the progression of polycystic kidney disease.
• [History of Russian psychiatry.]
• [Not Available.]