FOXP3 actively represses transcription by recruiting the HAT/HDAC complex.

FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Research Abstract Details 

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FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Abstract Text:

Bin Li,Mark I Greene,Bin Li,Mark I Greene,

The Forkhead box protein P3 (FOXP3) is a master cell lineage modulator in CD4(+)CD25(+) natural regulatory T cell (Treg) development. The Treg set of cells, also called T suppressor cells, play an essential role in natural Treg-mediated suppression of various types of immune cells. Suppression can be manifest by a cell-cell contact set of events, and recent evidence also supports soluble mediators. FOXP3 was previous identified as a passive transcriptional repressor which associates with nuclear factor of activated T-cells, cytoplasmic, and calcineurin-dependent 2 (NFATc2) as well as several other transcriptional factors including nuclear factor kappa-B (NFkappaB) and acute myeloid leukemia 1(AML1)/runt-related transcription factor 1(RUNX1). We found FOXP3 could actively repress transcription by recruiting distinct histone acetyltransferases and histone deacetylases to function as a co-repressor complex. The identification of enzymatic factors operative as essential participants in FOXP3-mediated transcriptional repression provides a practical basis for therapeutically modulating the activity of FOXP3 in immune suppression. Here we briefly summarize recent progress in our understanding of the biochemistry of FOXP3-mediated transcriptional regulation.

FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Publishing Authors By Initials

B Li,MI Greene,B Li,MI Greene,

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FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell cycle (Georgetown, Tex.)

VOLUME: 6

Page Numbers: 1432-6

Journal Abbreviation: Cell Cycle

ISSN: 1551-4005

DAY: 10

MONTH: 05

YEAR: 2007

FOXP3 actively represses transcription by recruiting the HAT/HDAC complex. Information

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LANGUAGE: eng

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AFFILIATION: Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

Country: United States

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MEDLINETA: Cell Cycle

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