FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development.

FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Research Abstract Details 

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FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Abstract Text:

Aaron B Steiner,Mark J Engleka,Qun Lu,Eileen C Piwarzyk,Sergey Yaklichkin,Julie L Lefebvre,James W Walters,Liliam Pineda-Salgado,Patricia A Labosky,Daniel S Kessler,

Induction and patterning of the mesodermal germ layer is a key early step of vertebrate embryogenesis. We report that FoxD3 function in the Xenopus gastrula is essential for dorsal mesodermal development and for Nodal expression in the Spemann organizer. In embryos and explants, FoxD3 induced mesodermal genes, convergent extension movements and differentiation of axial tissues. Engrailed-FoxD3, but not VP16-FoxD3, was identical to native FoxD3 in mesoderm-inducing activity, indicating that FoxD3 functions as a transcriptional repressor to induce mesoderm. Antagonism of FoxD3 with VP16-FoxD3 or morpholino-knockdown of FoxD3 protein resulted in a complete block to axis formation, a loss of mesodermal gene expression, and an absence of axial mesoderm, indicating that transcriptional repression by FoxD3 is required for mesodermal development. FoxD3 induced mesoderm in a non-cell-autonomous manner, indicating a role for secreted inducing factors in the response to FoxD3. Consistent with this mechanism, FoxD3 was necessary and sufficient for the expression of multiple Nodal-related genes, and inhibitors of Nodal signaling blocked mesoderm induction by FoxD3. Therefore, FoxD3 is required for Nodal expression in the Spemann organizer and this function is essential for dorsal mesoderm formation.

FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Publishing Authors By Initials

AB Steiner,MJ Engleka,Q Lu,EC Piwarzyk,S Yaklichkin,JL Lefebvre,JW Walters,L Pineda-Salgado,PA Labosky,DS Kessler,

For similar animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research abstracts see: animals: chordata: vertebrates: amphibia: anura: pipidae: xenopus: xenopus laevis research

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FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Development (Cambridge, England)

VOLUME: 133

Page Numbers: 4827-38

Journal Abbreviation: Development

ISSN: 0950-1991

DAY: 8

MONTH: 11

YEAR: 2006

FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701744

FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Keywords Mesh Terms:

KEYWORDS: Xenopus laevis

MESH TERMS: metabolism

Chemical & Substance for Abstract: FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. Information

Substance Name: nodal protein

Registry Number: 0

Grant and Affiliation Information for FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development.

AFFILIATION: Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

Country: England

AGENCY: United States NICHD

GRANT: HD36720

ACRONYM: HD

MEDLINETA: Development

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