FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Research Abstract Details 

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FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Abstract Text:

Mathieu Lupien, Eeckhoute,Clifford A Meyer,Qianben Wang,Yong Zhang,Wei Li,Jason S Carroll,X Shirley Liu,Myles Brown,

Complex organisms require tissue-specific transcriptional programs, yet little is known about how these are established. The transcription factor FoxA1 is thought to contribute to gene regulation through its ability to act as a pioneer factor binding to nucleosomal DNA. Through genome-wide positional analyses, we demonstrate that FoxA1 cell type-specific functions rely primarily on differential recruitment to chromatin predominantly at distant enhancers rather than proximal promoters. This differential recruitment leads to cell type-specific changes in chromatin structure and functional collaboration with lineage-specific transcription factors. Despite the ability of FoxA1 to bind nucleosomes, its differential binding to chromatin sites is dependent on the distribution of histone H3 lysine 4 dimethylation. Together, our results suggest that methylation of histone H3 lysine 4 is part of the epigenetic signature that defines lineage-specific FoxA1 recruitment sites in chromatin. FoxA1 translates this epigenetic signature into changes in chromatin structure thereby establishing lineage-specific transcriptional enhancers and programs.

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Publishing Authors By Initials

M Lupien,J Eeckhoute,CA Meyer,Q Wang,Y Zhang,W Li,JS Carroll,XS Liu,M Brown,

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FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cell

VOLUME: 132

Page Numbers: 958-70

Journal Abbreviation: Cell

ISSN: 1097-4172

DAY: 21

MONTH: Mar

YEAR: 2008

FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription. Information

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LANGUAGE: eng

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Grant and Affiliation Information for FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription.

AFFILIATION: Division of Molecular and Cellular Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: R01DK074967

ACRONYM: DK

MEDLINETA: Cell

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