Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy?

Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy? Research Abstract Details 

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Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy? Abstract Text:

Twelve subjects with minimal expression of the myotonic dystrophy (MyD) gene were investigated by retinal densitometry, a technique which has been used to study the properties of photopigments in the living eye and to detect photoreceptor abnormalities. Other investigations included slit-lamp examination, funduscopy, raleigh matches with the anomaloscope, tonometry, and neurological examination, including electroretinography (ERG) and pattern visual evoked potentials recording. Foveal densitometry demonstrated reduced values of the macular photopigment density difference with normal photopigment kinetics in early phases of the disease, even in asymptomatic individuals. The densitometric values correlated with decreased amplitudes of the photopic ERG a-wave. These findings may be explained by loss or dysfunction of the outer segments of foveal receptors. It is yet unknown whether or not these changes are secondary to other observed neuroretinal abnormalities in MyD. The most likely explanation might be an abnormality of the Na, Ca:K exchanger at the level of the outer segments of the photoreceptors whether or not in combination with a dysfunction of voltage generation systems, involving both photoreceptors and retinal pigment epithelium.

Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy? Publishing Authors By Initials

For similar biological factors: pigments, biological: retinal pigments research abstracts see: biological factors: pigments, biological: retinal pigments research

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Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy? Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The British journal of ophthalmology

VOLUME: 76

Page Numbers: 594-7

Journal Abbreviation: Br J Ophthalmol

ISSN: 0007-1161

DAY: 28

MONTH: Oct

YEAR: 1992

Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy? Information

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LANGUAGE: eng

NlmUniqueID: 421041

Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy? Keywords Mesh Terms:

KEYWORDS: Retinal Pigments

MESH TERMS: physiology

Chemical & Substance for Abstract: Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy? Information

Substance Name: Retinal Pigments

Registry Number: 0

Grant and Affiliation Information for Foveal photopigment kinetics--abnormality: an early sign in myotonic dystrophy?

AFFILIATION: Department of Neurology, de Wever Hospital, Heerlen, The Netherlands.

Country: ENGLAND

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MEDLINETA: Br J Ophthalmol

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