Forward-time simulations of human populations with complex diseases.

Forward-time simulations of human populations with complex diseases. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Forward-time simulations of human populations with complex diseases. Abstract Text:

Bo Peng,Christopher I Amos,Marek Kimmel,

Due to the increasing power of personal computers, as well as the availability of flexible forward-time simulation programs like simuPOP, it is now possible to simulate the evolution of complex human diseases using a forward-time approach. This approach is potentially more powerful than the coalescent approach since it allows simulations of more than one disease susceptibility locus using almost arbitrary genetic and demographic models. However, the application of such simulations has been deterred by the lack of a suitable simulation framework. For example, it is not clear when and how to introduce disease mutants-especially those under purifying selection-to an evolving population, and how to control the disease allele frequencies at the last generation. In this paper, we introduce a forward-time simulation framework that allows us to generate large multi-generation populations with complex diseases caused by unlinked disease susceptibility loci, according to specified demographic and evolutionary properties. Unrelated individuals, small or large pedigrees can be drawn from the resulting population and provide samples for a wide range of study designs and ascertainment methods. We demonstrate our simulation framework using three examples that map genes associated with affection status, a quantitative trait, and the age of onset of a hypothetical cancer, respectively. Nonadditive fitness models, population structure, and gene-gene interactions are simulated. Case-control, sibpair, and large pedigree samples are drawn from the simulated populations and are examined by a variety of gene-mapping methods.

Forward-time simulations of human populations with complex diseases. Publishing Authors By Initials

B Peng,CI Amos,M Kimmel,

For similar natural sciences: time research abstracts see: natural sciences: time research

PUBMED ID PMID:

MEDLINE DATE:

Forward-time simulations of human populations with complex diseases. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: PLoS genetics

VOLUME: 3

Page Numbers: e47

Journal Abbreviation: PLoS Genet.

ISSN: 1553-7404

DAY: 15

MONTH: 02

YEAR: 2007

Forward-time simulations of human populations with complex diseases. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101239074

Forward-time simulations of human populations with complex diseases. Keywords Mesh Terms:

KEYWORDS: Time

MESH TERMS: pathology

Chemical & Substance for Abstract: Forward-time simulations of human populations with complex diseases. Information

Substance Name: Genetic Markers

Registry Number: 0

Grant and Affiliation Information for Forward-time simulations of human populations with complex diseases.

AFFILIATION: Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America. bpeng@mdanderson.org

Country: United States

AGENCY: United States NIEHS

GRANT: ES09912

ACRONYM: ES

MEDLINETA: PLoS Genet

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Forward-time simulations of human populations with complex diseases Related Publications

• A two-color acid-free cartilage and bone stain for zebrafish larvae.
• Adherence to warfarin assessed by electronic pill caps, clinician assessment, and patient reports: results from the IN-RANGE study.
• Demosaicing: image reconstruction from color CCD samples.
• Deterministic and Stochastic Models of NFkappaB Pathway.
• Down-scaling for better transform compression.
• Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys.
• Forward-time simulations of human populations with complex diseases.
• Health-related quality of life in the era of erythropoietin.
• Hydrogen Bonding, H-D Exchange, and Molecular Mobility in Thin Water Films on TiO2(110).
• Interpretation of skeletal variations for human risk assessment: delayed ossification and wavy ribs.
• Low bit-rate compression of facial images.
• Mechanism of action, pharmacokinetic and pharmacodynamic profile, and clinical applications of nitrogen-containing bisphosphonates.
• Modeling photothermal and acoustical induced microbubble generation and growth.
• Monoamine transporters and psychostimulant addiction.
• Psychosocial aspects of chronic disease: ESRD as a paradigmatic illness.
• Routine vaccines across the life span, 2007.
• Screening, diagnosis, and treatment of depression in patients with end-stage renal disease.
• Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling.
• Site-dependent electron-stimulated reactions in water films on TiO(2)(110).
• Tbx16 cooperates with Wnt11 in assembling the zebrafish organizer.
• Ultrasound-induced angiogenic response in endothelial cells.
• Warfarin and cytochrome P450 2C9 genotype: possible ethnic variation in warfarin sensitivity.
• Warfarin response and vitamin K epoxide reductase complex 1 in African Americans and Caucasians.
• [Ergonomics in the dental laboratories]
• [Ergonomy in dental laboratories. 2. Drilling--grinding--polishing]
• [Ergonomy in the dental laboratory. 3. The cooperation between dentist and dental technician]
• [Expert's meeting in Paris: dental exhibition a notable success]
• [The FDI specifications]
• [The XVI International Dental-Exhibition 1965 at Stuttgart. The exhibition program for the technicians. II]
• mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish.