Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices.

Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices. Research Abstract Details 

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Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices. Abstract Text:

Keat Theng Chow,Lai Wah Chan,Paul W S Heng,

PURPOSE: This study was aimed at formulating a hydrophilic non-aqueous gel for topical delivery of the model moisture-sensitive drug, minocycline hydrochloride (MH). METHODS: Stability study of MH dissolved in water and various hydrophilic non-aqueous solvents was performed over a period of four months in order to select a suitable non-aqueous solvent for MH gel. To improve MH stability, the effect of different cation additives on MH stability in the selected solvent was investigated. Non-aqueous gel matrices were prepared from three different types of hydrophilic polymers in glycerin-propylene glycol mixture with Mg(2+) cation additive. Oscillatory shear rheometry was performed on the gel matrices using a cone-and-plate rheometer. RESULTS: MH stability was affected by the type of solvent employed and the duration of storage. Different cation additives affected the extent of MH stabilization through MH-cation complex formation. Rheological properties of the non-aqueous gel matrices were significantly affected by the type and concentration of polymer, and the vehicle ratios in the formulations. CONCLUSIONS: MH stabilization could be achieved using the selected glycerin-propylene glycol mixture containing MgCl(2). Gel matrix formulated using this solvent system and 3%w/w N-vinylacetamide/sodium acrylate copolymer had demonstrated the most favorable rheological properties as a gel for topical application.

Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices. Publishing Authors By Initials

KT Chow,LW Chan,PW Heng,

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Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutical research

VOLUME: 25

Page Numbers: 207-17

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 2

MONTH: 10

YEAR: 2007

Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Formulation of hydrophilic non-aqueous gel: drug stability in different solvents and rheological behavior of gel matrices.

AFFILIATION: Department of Pharmacy, Faculty of Science, National University of Singapore, 18 Science Drive 4, Singapore, 117543, Singapore, phapaulh@nus.edu.sg.

Country: United States

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MEDLINETA: Pharm Res

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