Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity.

Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity. Research Abstract Details 

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Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity. Abstract Text:

Dusan Kuzma,Masood Parvez,Thomas George Back,

The oxidation of 2,2'-selenobis(benzamide) with N-chlorosuccinimide or hydrogen peroxide afforded the corresponding stable azaselenonium chloride and hydroxide, respectively. Both structures were characterized by spectroscopic and X-ray crystallographic methods. Each contains a covalent N-Se bond, as well as a noncovalent interaction between the selenium atom and the carbonyl oxygen atom of the other amide moiety. The treatment of the azaselenonium chloride with an excess of potassium hydride in DMSO-d(6) afforded the corresponding spirodiazaselenurane species, which proved hydrolytically unstable, but was characterized by NMR spectroscopy. The azaselenonium chloride displayed significant glutathione peroxidase-like catalytic activity in an assay with benzyl thiol and either hydrogen peroxide or tert-butyl hydroperoxide.

Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity. Publishing Authors By Initials

D Kuzma,M Parvez,TG Back,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: energy metabolism: oxidation-reduction research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: energy metabolism: oxidation-reduction research

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Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Organic & biomolecular chemistry

VOLUME: 5

Page Numbers: 3213-7

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 29

MONTH: 08

YEAR: 2007

Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity. Information

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LANGUAGE: eng

NlmUniqueID: 101154995

Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity. Keywords Mesh Terms:

KEYWORDS: Oxidation-Reduction

MESH TERMS: chemistry

Chemical & Substance for Abstract: Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity. Information

Substance Name: Glutathione Peroxidase

Registry Number: EC 1.11.1.9

Grant and Affiliation Information for Formation of a spirodiazaselenurane and its corresponding azaselenonium derivatives from the oxidation of 2,2'-selenobis(benzamide). Structure, properties and glutathione peroxidase activity.

AFFILIATION: Department of Chemistry, University of Calgary, Calgary, AB, Canada.

Country: England

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MEDLINETA: Org Biomol Chem

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