Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Abstract Text:

Sangkyou Lee,Joon Jeong,Tadeusz Majewski,Steven E Scherer,Mi-Sook Kim,Tomasz Tuziak,Kuang S Tang,Keith Baggerly,Herbert Barton Grossman,Jain-Hua Zhou,Lanlan Shen,Jolanta Bondaruk,Saira S Ahmed,Susmita Samanta,Philippe Spiess,Xifeng Wu,Slawomir Filipek,David McConkey,Menashe Bar-Eli,Jean-Pierre Issa,William F Benedict,Bogdan Czerniak,

We used human bladder cancer as a model system and the whole-organ histologic and genetic mapping strategy to identify clonal genetic hits associated with growth advantage, tracking the evolution of bladder cancer from intraurothelial precursor lesions. Six putative chromosomal regions critical for clonal expansion of intraurothelial neoplasia and development of bladder cancer were identified by using this approach. Focusing on one of the regions, which includes the model tumor suppressor RB1, we performed allelotyping of single-nucleotide polymorphic sites and identified a 1.34-Mb segment around RB1 characterized by a loss of polymorphism associated with the initial expansion of in situ neoplasia. This segment contains several positional candidate genes referred to by us as forerunner genes that may contribute to such expansion. We subsequently concentrated our efforts on the two neighbor genes flanking RB1, namely ITM2B and CHC1L, as well as P2RY5, which is located inside RB1. Here, we report that ITM2B and P2RY5 modulated cell survival and were silenced by methylation or point mutations, respectively, and thus by functional loss may contribute to the growth advantage of neoplasia. We also show that homozygous inactivation of P2RY5 was antecedent to the loss of RB1 during tumor development, and that nucleotide substitutions in P2RY5 represent a cancer predisposing factor.

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Publishing Authors By Initials

S Lee,J Jeong,T Majewski,SE Scherer,MS Kim,T Tuziak,KS Tang,K Baggerly,HB Grossman,JH Zhou,L Shen,J Bondaruk,SS Ahmed,S Samanta,P Spiess,X Wu,S Filipek,D McConkey,M Bar-Eli,JP Issa,WF Benedict,B Czerniak,

For similar neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 13732-7

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 16

MONTH: 08

YEAR: 2007

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder Neoplasms

MESH TERMS: genetics

Chemical & Substance for Abstract: Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Information

Substance Name: Retinoblastoma Protein

Registry Number: 0

Grant and Affiliation Information for Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.

AFFILIATION: Department of Pathology, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Country: United States

AGENCY: United States NCI

GRANT: U01CA85078

ACRONYM: CA

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia Related Publications

• Combined interventional radiological and endoscopical approach for the treatment of a postoperative biliary stricture and fistula.
• Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia.
• Quantitation of aurora kinase a gene copy number in urine sediments and bladder cancer detection.
• The treatment of tumours of the bladder by radioactive bromide; preliminary report.
• Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy.
• [Free amino acids of some edible mushrooms]
• [Free, N-substituted and peptide amino acids in urine of patients with chronic renal insufficiency]
• [In memory of V.Z. Czerniak (on the 75th anniversary of his birth)]
• [Quantitative determination of amino acids using photometry of negative printed chromatograms]
• [Studies on the possibility of determination of mushroom species according to the composition of their amino acids]