Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis.

Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Research Abstract Details 

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Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Abstract Text:

OBJECTIVE: To assess the presence of foreign material in the granulomatous cutaneous lesions of patients with systemic sarcoidosis. DESIGN AND SETTING: Observational study reevaluating histological specimens at a university referral hospital. PATIENTS: Sixty-five patients diagnosed as having sarcoidosis who developed granulomatous cutaneous involvement. MAIN OUTCOME MEASURES: To detect the presence of polarizable foreign particles in cutaneous biopsy specimens and to evaluate the association with clinical features of the patients. RESULTS: Granulomatous cutaneous involvement was demonstrated in 65 (15.3%) of 425 patients with systemic sarcoidosis. In 14 (22%) of the 65 patients, the cutaneous biopsy specimen showed foreign particles in polarized light. The skin lesions corresponded to 3 different clinical patterns: an admixture of papules and infiltration of previously undetected minute scars (n = 6); scar sarcoidosis (n = 4); and subcutaneous nodules (n = 4). The lesions were located most frequently in the extremities, involving the knees in 10 patients. CONCLUSIONS: The presence of polarizable foreign body material in granulomatous cutaneous lesions is not infrequent in patients with systemic sarcoidosis. Inoculation of foreign matter from a previous inapparent minor trauma may induce granuloma formation in individuals with sarcoidosis.

Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Publishing Authors By Initials

For similar skin and connective tissue diseases: skin diseases research abstracts see: skin and connective tissue diseases: skin diseases research

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Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 137

Page Numbers: 427-30

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Apr

YEAR: 2001

Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis. Keywords Mesh Terms:

KEYWORDS: Skin Diseases

MESH TERMS: pathology

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Grant and Affiliation Information for Foreign bodies in granulomatous cutaneous lesions of patients with systemic sarcoidosis.

AFFILIATION: Department of Dermatology, Hospital de Bellvitge, Carrer Feixa Llarga s/n, Hospitalet de Llobregat, 08907 Barcelona, Spain. jmarcoval@csub.scs.es

Country: United States

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MEDLINETA: Arch Dermatol

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