Force transients and minimum cross-bridge models in muscular contraction.

Force transients and minimum cross-bridge models in muscular contraction. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Force transients and minimum cross-bridge models in muscular contraction. Abstract Text:

Two- and three-state cross-bridge models are considered and examined with respect to their ability to predict three distinct phases of the force transients that occur in response to step change in muscle fiber length. Particular attention is paid to satisfying the Le Châtelier-Brown Principle. This analysis shows that the two-state model can account for phases 1 and 2 of a force transient, but is barely adequate to account for phase 3 (delayed force) unless a stretch results in a sudden increase in the number of cross-bridges in the detached state. The three-state model [Formula: see text] makes it possible to account for all three phases if we assume that the [Formula: see text] transition is fast (corresponding to phase 2), the [Formula: see text] transition is of intermediate speed (corresponding to phase 3), and the [Formula: see text] transition is slow; in such a scenario, states A and C can support or generate force (high force states) but state B cannot (detached, or low-force state). This model involves at least one ratchet mechanism. In this model, force can be generated by either of two transitions: [Formula: see text] or [Formula: see text]. To determine which of these is the major force-generating step that consumes ATP and transduces energy, we examine the effects of ATP, ADP, and phosphate (Pi) on force transients. In doing so, we demonstrate that the fast transition (phase 2) is associated with the nucleotide-binding step, and that the intermediate-speed transition (phase 3) is associated with the Pi-release step. To account for all the effects of ligands, it is necessary to expand the three-state model into a six-state model that includes three ligand-bound states. The slowest phase of a force transient (phase 4) cannot be explained by any of the models described unless an additional mechanism is introduced. Here we suggest a role of series compliance to account for this phase, and propose a model that correlates the slowest step of the cross-bridge cycle (transition [Formula: see text]) to: phase 4 of step analysis, the rate constant k (tr) of the quick-release and restretch experiment, and the rate constant k (act) for force development time course following Ca(2+) activation.

Force transients and minimum cross-bridge models in muscular contraction. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Force transients and minimum cross-bridge models in muscular contraction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of muscle research and cell motility

VOLUME: 28

Page Numbers: 371-95

Journal Abbreviation: J. Muscle Res. Cell. Motil.

ISSN: 0142-4319

DAY: 19

MONTH: 04

YEAR: 2008

Force transients and minimum cross-bridge models in muscular contraction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8006298

Force transients and minimum cross-bridge models in muscular contraction. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Force transients and minimum cross-bridge models in muscular contraction. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Force transients and minimum cross-bridge models in muscular contraction.

AFFILIATION: Department of Anatomy and Cell Biology, University of Iowa, Iowa City, IA, 52245, USA, Masataka-kawai@uiowa.edu.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Muscle Res Cell Motil

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Force transients and minimum cross-bridge models in muscular contraction Related Publications

• A precipitin test for antigens present in mouse tissues containing the milk agent.
• Effectively managing your collection agencies.
• Efficacy of avridine and liposomes as adjuvants for avian influenza virus antigens in Turkeys.
• Force transients and minimum cross-bridge models in muscular contraction.
• Glycoprotein gene truncation in avian metapneumovirus subtype C isolates from the United States.
• Human metapneumovirus in turkey poults.
• Liver receptor homologue-1 regulates gonadotrope function.
• Metabolic control of beta-glucosidase synthesis in yeast.
• On the role of the inducer in the synthesis of maltase in yeast.
• Purification and properties of an inducible beta-glucosidase of yeast.
• Purification of mouse poliomyelitis virus by methanol precipitation at low temperatures.
• The components of maltozymase in yeast, and their behavior during deadaptation.
• The effect of glucose repression on the level of ribosomalbound beta-glucosidase.
• The identification of a ribosomal-bound beta-glucosidase.
• The specificity of induction of beta-glucosidase in Saccharomyces cerevisiae.
• Understanding the trade-offs of the Canadian health system.
• We're in it together. An unlikely partnership is leading a movement toward meaningful reform.