Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus.

Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus. Research Abstract Details 

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Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus. Abstract Text:

Jafar Sharif,Michiyo Nakamura,Takuya Ito,Yoshitaka Kimura,Teruyuki Nagamune,Kohzoh Mitsuya,Kunihiro Okamura,

Biological responses to environmental effects are mediated through epigenetic changes such as chemical modifications of the histone tails and DNA (5-cytosine) methylation. We report that dietary protein restriction in pregnant mice can alter histone modifications in the promoter region of the Igf2 gene and cause a two-fold repression in promoter specific Igf2 transcription in the liver of the fetus. Suppression of Igf2 is accompanied with low birth weight of the pups born to the protein-restricted dams. Our results provide new information about the epigenetic aspects of early life programming and will improve our understanding about the developmental origins of adult diseases.

Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus. Publishing Authors By Initials

J Sharif,M Nakamura,T Ito,Y Kimura,T Nagamune,K Mitsuya,K Okamura,

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Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

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Page Numbers: 125-6

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Food restriction in pregnant mice can induce changes in histone modifications and suppress gene expression in fetus. Information

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LANGUAGE: eng

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AFFILIATION: Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. jafarsharif@tubero.tohoku.ac.jp

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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