Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses.

Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses. Research Abstract Details 

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Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses. Abstract Text:

Johanna A Smith, Daniel,

Numerous host cellular cofactors are involved in the life cycle of retroviruses. Importantly, DNA repair machinery of infected cells is activated by retroviruses and retroviral vectors during the process of integration and host cell DNA repair proteins are employed to create a fully integrated provirus. The full delineation of these repair mechanisms that are triggered by retroviruses also has implications outside of the field of retrovirology. It will undoubtedly be of interest to developers of gene therapy and will also further facilitate our understanding of DNA repair and cancer. This review gives a brief summary of the accomplishments in the field of DNA repair and retroviral integration and the opportunities that this area of science provides with regards to the elucidation of repair mechanisms, in the context of retroviral infection.

Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses. Publishing Authors By Initials

JA Smith,R Daniel,

For similar virus diseases: rna virus infections: retroviridae infections research abstracts see: virus diseases: rna virus infections: retroviridae infections research

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Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses. Journal Published:

PUBLICATION TYPE: Review

Journal: ACS chemical biology

VOLUME: 1

Page Numbers: 217-26

Journal Abbreviation: ACS Chem. Biol.

ISSN: 1554-8937

DAY: 23

MONTH: May

YEAR: 2006

Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses. Information

Number of References: 89

LANGUAGE: eng

NlmUniqueID: 101282906

Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses. Keywords Mesh Terms:

KEYWORDS: Retroviridae Infections

MESH TERMS: virology

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Grant and Affiliation Information for Following the path of the virus: the exploitation of host DNA repair mechanisms by retroviruses.

AFFILIATION: Division of Infectious Diseases--Center for Human Virology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, Pennsylvania 19107, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA98090

ACRONYM: CA

MEDLINETA: ACS Chem Biol

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