Folding versus aggregation: polypeptide conformations on competing pathways.

Folding versus aggregation: polypeptide conformations on competing pathways. Research Abstract Details 

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Folding versus aggregation: polypeptide conformations on competing pathways. Abstract Text:

Thomas R Jahn,Sheena E Radford,Thomas R Jahn,Sheena E Radford,

Protein aggregation has now become recognised as an important and generic aspect of protein energy landscapes. Since the discovery that numerous human diseases are caused by protein aggregation, the biophysical characterisation of misfolded states and their aggregation mechanisms has received increased attention. Utilising experimental techniques and computational approaches established for the analysis of protein folding reactions has ensured rapid advances in the study of pathways leading to amyloid fibrils and amyloid-related aggregates. Here we describe recent experimental and theoretical advances in the elucidation of the conformational properties of dynamic, heterogeneous and/or insoluble protein ensembles populated on complex, multidimensional protein energy landscapes. We discuss current understanding of aggregation mechanisms in this context and describe how the synergy between biochemical, biophysical and cell-biological experiments are beginning to provide detailed insights into the partitioning of non-native species between protein folding and aggregation pathways.

Folding versus aggregation: polypeptide conformations on competing pathways. Publishing Authors By Initials

TR Jahn,SE Radford,TR Jahn,SE Radford,

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Folding versus aggregation: polypeptide conformations on competing pathways. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of biochemistry and biophysics

VOLUME: 469

Page Numbers: 100-17

Journal Abbreviation: Arch. Biochem. Biophys.

ISSN: 1096-0384

DAY: 8

MONTH: 06

YEAR: 2007

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LANGUAGE: eng

NlmUniqueID: 372430

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Grant and Affiliation Information for Folding versus aggregation: polypeptide conformations on competing pathways.

AFFILIATION: Astbury Centre for Structural and Molecular Biology, Institute of Molecular and Cellular Biology, University of Leeds, Mount Preston Street, Leeds LS2 9JT, UK.

Country: United States

AGENCY: United Kingdom Wellcome T

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MEDLINETA: Arch Biochem Biophys

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