Folding of proteins with diverse folds.

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Folding of proteins with diverse folds. Abstract Text:

Sandipan Mohanty,Ulrich H E Hansmann,

Using parallel tempering simulations with high statistics, we investigate the folding and thermodynamic properties of three small proteins with distinct native folds: the all-helical 1RIJ, the all-sheet beta3s, and BBA5, which has a mixed helix-sheet fold. In all three cases, simulations with our energy function find the native structures as global minima in free energy at experimentally relevant temperatures. However, the folding process strongly differs for the three molecules, indicating that the folding mechanism is correlated with the form of the native structure.

Folding of proteins with diverse folds. Publishing Authors By Initials

S Mohanty,UH Hansmann,

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Folding of proteins with diverse folds. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biophysical journal

VOLUME: 91

Page Numbers: 3573-8

Journal Abbreviation: Biophys. J.

ISSN: 0006-3495

DAY: 1

MONTH: 09

YEAR: 2006

Folding of proteins with diverse folds. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370626

Folding of proteins with diverse folds. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Folding of proteins with diverse folds. Information

Substance Name: Proteins

Registry Number: 0

Grant and Affiliation Information for Folding of proteins with diverse folds.

AFFILIATION: John von Neumann Institut für Computing, Forschungszentrum Jülich, Jülich, Germany.

Country: United States

AGENCY: United States NIGMS

GRANT: GM62838

ACRONYM: GM

MEDLINETA: Biophys J

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