Folate-related genes and the risk of tobacco-related cancers in Central Europe.

Folate-related genes and the risk of tobacco-related cancers in Central Europe. Research Abstract Details 

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Folate-related genes and the risk of tobacco-related cancers in Central Europe. Abstract Text:

Rayjean J Hung,Mia Hashibe,James McKay,Valerie Gaborieau,Neonila Szeszenia-Dabrowska,David Zaridze,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Ioan Mates,Lenka Foretova,Vladimir Janout,Vladimir Bencko,Amelie Chabrier,Norman Moullan,Federico Canzian,Janet Hall,Paolo Boffetta,Paul Brennan,

Folate has been hypothesized to protect against aero-digestive cancers although the evidence is not yet conclusive due to possible confounding by other dietary factors. Sequence variants in folate pathway were suggested to be associated with plasma folate levels and are unlikely to be confounded by other lifestyle factors. We therefore investigated the effects of key folate genetic variants on the risk of aero-digestive cancers and their potential effect modification by folate intake in a multicenter study in Central Europe. A total of 2250 lung cases, 811 upper aero-digestive tract cases and 2899 controls were recruited with blood samples. The methylenetetrahydrofolate reductase (MTHFR) C677T variant was associated with an increased risk of lung cancer with an odds ratio (OR) for homozygote variant of 1.37 [95% confidence interval (CI) = 1.10-1.71]. The two MTHFR variants were in strong linkage disequilibrium, and 677T-1298A appeared to be the primary haplotype associated with cancer risk. The risk estimates for MTHFR 677T/677T genotype was more prominent among lung cancer patients with young onset (OR = 1.92, 95% CI = 1.12-3.29). When stratified by dietary intake of folate, the effect of the MTHFR 677T variant was more prominent among subjects with low intake of folate: the ORs for 677T/677T genotype among subjects with the lowest decile were 2.60 (95% CI = 1.39-4.88) and 4.14 (95% CI = 1.47-11.7) for lung and upper aero-digestive tract cancer, respectively. In conclusion, we identified a moderate effect of MTHFR C677T on lung cancer risk and a possible effect modification by folate intake that is consistent with the functional data. These results support an important role of folate in protecting against tobacco-related cancers.

Folate-related genes and the risk of tobacco-related cancers in Central Europe. Publishing Authors By Initials

RJ Hung,M Hashibe,J McKay,V Gaborieau,N Szeszenia-Dabrowska,D Zaridze,J Lissowska,P Rudnai,E Fabianova,I Mates,L Foretova,V Janout,V Bencko,A Chabrier,N Moullan,F Canzian,J Hall,P Boffetta,P Brennan,

For similar plants: plant families and groups: angiosperms: solanaceae: tobacco research abstracts see: plants: plant families and groups: angiosperms: solanaceae: tobacco research

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MEDLINE DATE:

Folate-related genes and the risk of tobacco-related cancers in Central Europe. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Carcinogenesis

VOLUME: 28

Page Numbers: 1334-40

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 26

MONTH: 03

YEAR: 2007

Folate-related genes and the risk of tobacco-related cancers in Central Europe. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Folate-related genes and the risk of tobacco-related cancers in Central Europe. Keywords Mesh Terms:

KEYWORDS: Tobacco

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Folate-related genes and the risk of tobacco-related cancers in Central Europe. Information

Substance Name: 5-Methyltetrahydrofolate-Homocysteine S-

Registry Number: EC 2.1.1.13

Grant and Affiliation Information for Folate-related genes and the risk of tobacco-related cancers in Central Europe.

AFFILIATION: International Agency for Research on Cancer, 150 cours Albert Thomas, F-69372, 69008, Lyon Cedex 08, France. hung@iarc.fr

Country: England

AGENCY: United States NCI

GRANT: R01 CA092039-01A2

ACRONYM: CA

MEDLINETA: Carcinogenesis

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