FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.

FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Research Abstract Details 

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FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Abstract Text:

Alleda E Flagg,Judy U Earley,Eric C Svensson,

Development of the heart valves is a complex process that relies on the successful remodeling of endocardial cushions. This process is dependent on a number of transcriptional regulators, including GATA4 and its interacting partner FOG-2. We have previously shown that the endocardial cushions in FOG-2 deficient mice are hyperplastic and fail to remodel appropriately, suggesting a defect late in endocardial cushion development. To elucidate this defect, we examined the later steps in endocardial cushion development including mesenchymal cell proliferation, differentiation, and apoptosis. We also measured myocardialization and endothelial-to-mesenchymal transformation (EMT) using previously described in vitro assays. We found no difference in the ability of the endocardial cushions to undergo myocardialization or in the rates of mesenchymal cell proliferation, differentiation, or apoptosis in the FOG-2 deficient cushions when compared to wild-type controls. However, using a collagen gel invasion assay, we found a 78% increase in outflow tract cushion EMT and a 35% increase in atrioventricular cushion EMT in the FOG-2 deficient mice when compared with wild-type mice. Taken together with GATA4's known role in promoting EMT, these results suggest that FOG-2 functions in cardiac valve formation as an attenuator of EMT by repressing GATA4 activity within the developing endocardial cushions.

FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Publishing Authors By Initials

AE Flagg,JU Earley,EC Svensson,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental biology

VOLUME: 304

Page Numbers: 308-16

Journal Abbreviation: Dev. Biol.

ISSN: 0012-1606

DAY: 21

MONTH: 12

YEAR: 2006

FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372762

FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart. Information

Substance Name: Zfpm2 protein, mouse

Registry Number: 0

Grant and Affiliation Information for FOG-2 attenuates endothelial-to-mesenchymal transformation in the endocardial cushions of the developing heart.

AFFILIATION: Department of Medicine, University of Chicago, Section of Cardiology, 5841 S. Maryland Ave, MC6088, Chicago, IL 60637, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL071063-05

ACRONYM: HL

MEDLINETA: Dev Biol

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