Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets.

Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets. Research Abstract Details 

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Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets. Abstract Text:

L Xia,T A Damon,J C Leiter,D Bartlett,

The laryngeal chemoreflex (LCR), elicited by a drop of water in the larynx, is exaggerated by mild hyperthermia (body temperature = 40-41 degrees C) in neonatal piglets. We tested the hypothesis that thermal prolongation of the LCR results from heating the nucleus of the solitary tract (NTS), where laryngeal afferents first form synapses in the brain stem. Three- to 13-day-old piglets were decerebrated and vagotomized and studied without anesthesia while paralyzed and ventilated. Phrenic nerve activity and rectal temperature were recorded. A thermode was placed in the medulla, and the brain tissue temperature was recorded with a thermistor approximately 1 mm from the tip of the thermode. When the thermode was inserted into the brain stem, respiratory activity was arrested or greatly distorted in eight animals. However, the thermode was inserted in nine animals without disrupting respiratory activity, and in these animals, warming the medullary thermode (thermistor temperature = 40-41 degrees C) while holding rectal temperature constant reversibly exaggerated the LCR. The caudal raphé was warmed focally by approximately 2 degrees C in four additional animals; this did not alter the duration of the LCR in these animals. Thermodes placed in the NTS did not disrupt respiratory activity, but they did prolong the LCR when warmed. Thermodes that were placed deep to the NTS in the region of the nucleus ambiguus disrupted respiratory activity, which precluded any analysis of the LCR. We conclude that prolongation of the laryngeal chemoreflex by whole body hyperthermia originates from the elevation of brain tissue temperature within in the NTS.

Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets. Publishing Authors By Initials

L Xia,TA Damon,JC Leiter,D Bartlett,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 102

Page Numbers: 54-62

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 7

MONTH: 09

YEAR: 2006

Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets. Information

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LANGUAGE: eng

NlmUniqueID: 8502536

Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiology

Chemical & Substance for Abstract: Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets. Information

Substance Name: Neurotransmitter Agents

Registry Number: 0

Grant and Affiliation Information for Focal warming in the nucleus of the solitary tract prolongs the laryngeal chemoreflex in decerebrate piglets.

AFFILIATION: Department of Physiology, Dartmouth Medical School, Lebanon, NH 03756, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD-36379

ACRONYM: HD

MEDLINETA: J Appl Physiol

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