Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings.

Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings. Abstract Text:

Akio Kubota,Hiroaki Yamanaka,Hiroomi Okuyama,Jun Shiraishi,Hisayoshi Kawahara,Toshimichi Hasegawa,Takehisa Ueno,Hiroyuki Kitajima,Yuko Kuwae,Masahiro Nakayama,Akio Kubota,Hiroaki Yamanaka,Hiroomi Okuyama,Jun Shiraishi,Hisayoshi Kawahara,Toshimichi Hasegawa,Takehisa Ueno,Hiroyuki Kitajima,Yuko Kuwae,Masahiro Nakayama,

In Japan, mortality due to intestinal perforation has been increasing for the last 15 years, as the survival rate of extremely-low-birth-weight neonates (ELBWs) has been increasing. In our NICU, although the incidence of necrotizing enterocolitis has been decreasing, that of focal intestinal perforation (FIP) has been increasing. To elucidate the pathogenesis of FIP, a histological study was performed. For the last 20 years, in our NICU, 11 ELBWs with FIP, including one with multiple perforations and impending rupture, underwent laparotomy and enterostomy. The intestinal wall around the perforation was resected for histological study. Histological studies revealed well-developed ganglion cells in all the cases. Although some lymphocytic infiltration and hemorrhage were observed, no apparent neutrophilic infiltration, or necrotic change was identified in any case. No evidence of microcirculatory impairment was identified. The intestinal musculature discontinued abruptly with thinning in three cases, and without thinning in the others. The histology of impending rupture showed an absence of the muscularis with preservation of the remaining components of the bowel wall. The findings that the punched-out perforations had the appearance of Hirschsprung's disease, FIP exclusively occurred in ELBWs, and that neither mechanical obstruction nor necrotic change could be identified as the cause of the perforation suggest that immature bowel movement and congenital muscle defects may be involved in the pathogenesis of FIP.

Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings. Publishing Authors By Initials

A Kubota,H Yamanaka,H Okuyama,J Shiraishi,H Kawahara,T Hasegawa,T Ueno,H Kitajima,Y Kuwae,M Nakayama,A Kubota,H Yamanaka,H Okuyama,J Shiraishi,H Kawahara,T Hasegawa,T Ueno,H Kitajima,Y Kuwae,M Nakayama,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pediatric surgery international

VOLUME: 23

Page Numbers: 997-1000

Journal Abbreviation: Pediatr. Surg. Int.

ISSN: 0179-0358

DAY: 18

MONTH: Oct

YEAR: 2007

Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8609169

Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings.

AFFILIATION: Department of Pediatric Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, 840 Murodo-cho, Izumi, Osaka, 594-1101, Japan. kubota@mch.pref.osaka.jp

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Pediatr Surg Int

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings Related Publications

• Age-related changes in BDNF protein levels in human serum: differences between autism cases and normal controls.
• Antioxidant prenylated flavonoids from propolis collected in Okinawa, Japan.
• Assay of human gastric mucin as a natural antibiotic against Helicobacter pylori.
• Audio input device and method of controlling the same.
• Characterization of tableting using the OSDRC system.
• Deposition transfection technology using a DNA complex with a thermoresponsive cationic star polymer.
• Detection of natural killer T cells in the sinus mucosa from asthmatics with chronic sinusitis.
• Development of the wing-attached rod for acceleration of "Biotube" vascular grafts fabrication in vivo.
• Efficacy of Lignocaine plus Ketamine at Different Doses in the Prevention of Pain Due to Propofol Injection.
• Essential role of p53 in trophoblastic apoptosis induced in the developing rodent placenta by treatment with a DNA-damaging agent.
• First-principles calculations of hydrogen diffusion on rutile TiO2(110) surfaces.
• Focal intestinal perforation in extremely-low-birth-weight neonates: etiological consideration from histological findings.
• Gross total surgical removal of malignant glioma from the medulla oblongata: report of two adult cases with reference to surgical anatomy.
• HLA-DRB1*0410-restricted recognition of XAGE-1b37-48 peptide by CD4 T cells.
• Highly effective in vivo gene transfection by blocked star vector.
• Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice.
• MEGF10 is a mammalian ortholog of CED-1 that interacts with clathrin assembly protein complex 2 medium chain and induces large vacuole formation.
• Median raphe cyst with ciliated cells of the penis.
• Novel chalcones as probes for in vivo imaging of beta-amyloid plaques in Alzheimer's brains.
• Reduction of Propofol-Induced Pain through Pretreatment with Lidocaine and/or Flurbiprofen.
• Reduction of postoperative nausea and vomiting and analgesic requirement with dexamethasone in women undergoing general anesthesia for mastectomy.
• Revival of apoptotic cells that display early-stage dynamic membrane blebbing.
• Structure-activity relationship of chalcones and related derivatives as ligands for detecting of beta-amyloid plaques in the brain.
• The Utility of Formalin-fixed and Paraffin-embedded Tissue Blocks for Quantitative Analysis of N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase mRNA Expressed by Colorectal Cancer Cells.
• The influence of object-relative visuomotor set on express saccades.
• The role of trophinin, an adhesion molecule unique to human trophoblasts, in progression of colorectal cancer.
• What are "clinical practice guidelines"?
• [A case of recurrent breast cancer with multiple liver metastases responding to combination therapy of capecitabine and MPA]
• [Coronary spastic angina and it's associated diseases]
• [Osteoporosis in the patients with rheumatoid arthritis (3) : the efficacy and the selection of the osteoporosis therapeutic drug]