Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth.

Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Research Abstract Details 

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Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Abstract Text:

Naosuke Hoshina,Tohru Tezuka,Kazumasa Yokoyama,Hiroko Kozuka-Hata,Masaaki Oyama,Tadashi Yamamoto,Naosuke Hoshina,Tohru Tezuka,Kazumasa Yokoyama,Hiroko Kozuka-Hata,Masaaki Oyama,Tadashi Yamamoto,

In the central nervous system (CNS), myelination of axons occurs when oligodendrocyte progenitor cells undergo terminal differentiation, and initiate process formation and axonal ensheathment. Although Fyn, a member of the Src-family kinases (SFKs), plays an important role in this differentiation process, the substrates of Fyn in oligodendrocytes are largely unknown. Using mass spectrometric analysis, we identified focal adhesion kinase (FAK) as a tyrosine-phosphorylated protein in the rat-derived CG4 oligodendrocyte cell line. Tyrosine phosphorylation of FAK was enhanced during differentiation of CG4 cells in a Fyn-dependent manner. In addition, phosphorylation of FAK was stimulated by laminin, one of the ligands for integrin. Knockdown of FAK expression in CG4 cells suppressed process outgrowth on laminin. Rac1 and Cdc42 activities, which are required for oligodendrocyte process formation, were down-regulated in FAK-knockdown cells. Expression of wild-type (WT) FAK in FAK-knockdown CG4 cells restored outgrowth of processes, but the Y397F mutant lacking the autophosphorylation site did not. These results suggest that FAK/Fyn-mediated activation of Rac1 and Cdc42 is critical for laminin-induced outgrowth of oligodendrocyte processes.

Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Publishing Authors By Initials

N Hoshina,T Tezuka,K Yokoyama,H Kozuka-Hata,M Oyama,T Yamamoto,N Hoshina,T Tezuka,K Yokoyama,H Kozuka-Hata,M Oyama,T Yamamoto,

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Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genes to cells : devoted to molecular & cellular m

VOLUME: 12

Page Numbers: 1245-54

Journal Abbreviation: Genes Cells

ISSN: 1356-9597

DAY: 7

MONTH: Nov

YEAR: 2007

Focal adhesion kinase regulates laminin-induced oligodendroglial process outgrowth. Information

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LANGUAGE: eng

NlmUniqueID: 9607379

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AFFILIATION: Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Country: England

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MEDLINETA: Genes Cells

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