Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication.

Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication. Abstract Text:

Jason A Taylor,Lucia Vojtech,Ingrid Bahner,Donald B Kohn,Dorothee Von Laer,David W Russell,Robert E Richard,

Gene therapy has the potential to control human immunodeficiency virus (HIV) in patients who do not respond to traditional antiviral therapy. In this study, we tested foamy virus (FV) vectors expressing three anti-HIV transgenes, both individually and in a combination vector. The transgenes tested in this study are RevM10, a dominant negative version of the viral rev protein, Sh1, a short hairpin RNA directed against a conserved overlapping sequence of tat and rev, and membrane-associated C46 (maC46), a membrane-attached peptide that blocks HIV cell entry. FV vectors efficiently transduce hematopoietic stem cells and, unlike lentivirus (LV) vectors, do not share viral proteins with HIV. The titers of the FV vectors described in this study were not affected by anti-HIV transgenes. On a direct comparison of FV vectors expressing the individual transgenes, entry inhibition using the maC46 transgene was found to be the most effective at blocking HIV replication. A clinically relevant FV vector expressing three anti-HIV transgenes effectively blocked HIV infection in primary macrophages derived from transduced, peripheral blood CD34-selected cells and in a cell line used for propagating HIV, CEMx174. These results suggest that there are potential benefits of using FV vectors in HIV gene therapy.Molecular Therapy (2007) 16 1, 46-51. doi:10.1038/sj.mt.6300335.

Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication. Publishing Authors By Initials

JA Taylor,L Vojtech,I Bahner,DB Kohn,DV Laer,DW Russell,RE Richard,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular therapy : the journal of the American So

VOLUME: 16

Page Numbers: 46-51

Journal Abbreviation: Mol. Ther.

ISSN: 1525-0016

DAY: 23

MONTH: 10

YEAR: 2007

Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100890581

Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication.

AFFILIATION: 1Department of Medicine, University of Washington, Seattle, Washington, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Mol Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication Related Publications

• A novel GJA 1 mutation in oculo-dento-digital dysplasia with curly hair and hyperkeratosis.
• A simple method to determine kinetic deuterium isotope effects provides evidence that proton transfer to carbon proceeds over and not through the reaction barrier.
• A transition state analog for phosphate diester cleavage catalyzed by a small enzyme-like metal ion complex.
• An optimised methodology for the neurobehavioural assessment in rodents.
• Claisen-type addition of glycine to a pyridoxal iminium ion in water.
• Coming out to care: caregivers of gay and lesbian seniors in Canada.
• Covalent catalysis by pyridoxal: evaluation of the effect of the cofactor on the carbon acidity of glycine.
• Dissection of a genetic locus influencing renal function in the rat and its concordance with kidney disease loci on human chromosome 1q21.
• Energy expenditure: a critical determinant of energy balance with key hypothalamic controls.
• Enzymatic catalysis of proton transfer at carbon: activation of triosephosphate isomerase by phosphite dianion.
• Foamy Virus Vectors Expressing Anti-HIV Transgenes Efficiently Block HIV-1 Replication.
• Identification in the mould Hypocrea jecorina of a gene encoding an NADP(+): d-xylose dehydrogenase.
• Improvement of VO2max by cardiac output and oxygen extraction adaptation during intermittent versus continuous endurance training.
• Inhibition of humic substances mediated photooxygenation of furfuryl alcohol by 2,4,6-trimethylphenol. Evidence for reactivity of the phenol with humic triplet excited states.
• Malignant proliferating pilar tumors arising in KID syndrome: a report of two patients.
• Phenotypic Correction of alpha-Sarcoglycan Deficiency by Intra-arterial Injection of a Muscle-specific Serotype 1 rAAV Vector.
• Practical identifiability of photophysical parameters in photodynamic therapy.
• Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate.
• Rational design of transition-state analogues as potent enzyme inhibitors with therapeutic applications.
• Some major mycotoxins and their mycotoxicoses-An overview.
• Targeting the RNA-binding protein Sam68 as a treatment for cancer?
• The motivational interview.
• The motivational interview: In practice.
• Topical tacrolimus treatment for chronic dermatitis of the ear.
• Use of local area facilities for involvement in physical activity in Canada: insights for developing environmental and policy interventions.
• When does an intermediate become a transition state? Degenerate isomerization without competing racemization during solvolysis of (S)-1-(3-nitrophenyl)ethyl tosylate.
• Winning the battle for standardization. The U.S. Army Medical Department examines the EMR to develop a standardized process for medication reconciliation documentation.
• [Carbon dioxide laser therapy for anogenital warts in children.]
• [The lessons of Cleopatra or reflections on conter-transfer and borderlines.]
• [The prevalence of bilateral malignant uveal melanoma]