Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. Research Abstract Details 

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Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. Abstract Text:

Katsunori Nonogaki,Kana Nozue,Yukiko Takahashi,Nobuyuki Yamashita,Shuichi Hiraoka,Hiroaki Kumano,Tomifusa Kuboki,Yohsitomo Oka,Katsunori Nonogaki,Kana Nozue,Yukiko Takahashi,Nobuyuki Yamashita,Shuichi Hiraoka,Hiroaki Kumano,Tomifusa Kuboki,Yohsitomo Oka,

Serotonin (5-hydroxytryptamine; 5-HT) 2C receptors and the downstream melanocortin pathway are suggested to mediate the appetite-suppressing effects of 5-HT drugs such as m-chlorophenylpiperazine (mCPP) and fenfluramine. Here, we report that fluvoxamine (3-30 mg/kg), a selective serotonin reuptake inhibitor (SSRI), in the presence of SB 242084 (1-2 mg/kg), a selective 5-HT2C receptor antagonist, exerts appetite-suppressing effects while fluvoxamine or SB 242084 alone has no effect. The appetite-suppressing effects were attenuated in the presence of SB 224289 (5 mg/kg), a selective 5-HT1B receptor antagonist. Moreover, CP 94253 (5-10 mg/kg), a selective 5-HT1B receptor agonist, exerted appetite-suppressing effects and significantly increased hypothalamic pro-opiomelanocortin (POMC) and cocaine- and amphetamine-regulated transcript (CART) gene expression and decreased hypothalamic orexin gene expression. These results suggest that fluvoxamine and inactivation of 5-HT2C receptors exert feeding suppression through activation of 5-HT1B receptors, and that 5-HT1B receptors up-regulate hypothalamic POMC and CART gene expression and down-regulate hypothalamic orexin gene expression in mice.

Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. Publishing Authors By Initials

K Nonogaki,K Nozue,Y Takahashi,N Yamashita,S Hiraoka,H Kumano,T Kuboki,Y Oka,K Nonogaki,K Nozue,Y Takahashi,N Yamashita,S Hiraoka,H Kumano,T Kuboki,Y Oka,

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Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The international journal of neuropsychopharmacolo

VOLUME: 10

Page Numbers: 675-81

Journal Abbreviation: Int. J. Neuropsychopharmacol.

ISSN: 1461-1457

DAY: 7

MONTH: 09

YEAR: 2006

Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors. Information

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LANGUAGE: eng

NlmUniqueID: 9815893

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Grant and Affiliation Information for Fluvoxamine, a selective serotonin reuptake inhibitor, and 5-HT2C receptor inactivation induce appetite-suppressing effects in mice via 5-HT1B receptors.

AFFILIATION: Center of Excellence, Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Japan. knonogaki-tky@umin.ac.jp

Country: England

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MEDLINETA: Int J Neuropsychopharmacol

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