Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology.

Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Research Abstract Details 

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Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Abstract Text:

Julian R Keith,Ying Wu,Jonathon R Epp,Robert J Sutherland,

Chronic fluoxetine increases neurogenesis in the dentate gyrus (DG). In view of the widespread clinical use of fluoxetine and the well-established role of the DG in memory, surprisingly few studies have examined the effects of fluoxetine on memory and hippocampal electrophysiology. Additionally, few studies have evaluated the potential for fluoxetine to promote recovery of function after DG damage. Therefore, we studied the effects of long-term administration of fluoxetine on both spatial-reference memory and working memory, recovery of function after intrahippocampal colchicine infusions, which can destroy 50-70% of DG granule cells, and electrophysiological responses in the DG to perforant path stimulation in freely moving rats. Chronic fluoxetine did not affect matching-to-place or reference-memory performance in intact rats in the Morris water-maze task. Surprisingly, in rats with DG damage, recovery of function on both tasks was adversely affected by chronic fluoxetine. Finally, unlike an earlier study that reported fluoxetine-induced increases in hippocampal population spike amplitudes and excitatory postsynaptic potential slopes in urethane-anesthetized rats, electrophysiological measures in DG of freely moving rats were not affected by chronic fluoxetine treatment.

Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Publishing Authors By Initials

JR Keith,Y Wu,JR Epp,RJ Sutherland,

For similar synaptic transmission research abstracts see: synaptic transmission research

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Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Behavioural pharmacology

VOLUME: 18

Page Numbers: 521-31

Journal Abbreviation:

ISSN: 0955-8810

DAY: 3

MONTH: Sep

YEAR: 2007

Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9013016

Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: drug effects

Chemical & Substance for Abstract: Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology. Information

Substance Name: Colchicine

Registry Number: 64-86-8

Grant and Affiliation Information for Fluoxetine and the dentate gyrus: memory, recovery of function, and electrophysiology.

AFFILIATION: Department of Psychology, University of North Carolina at Wilmington, North Carolina 28403-5612, USA. keithj@uncw.edu

Country: England

AGENCY: United States NIMH

GRANT: MH06715601A1

ACRONYM: MH

MEDLINETA: Behav Pharmacol

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