Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers.

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers. Abstract Text:

Qisheng Zhang,Hejun Lu,Cyrille Richard,Dennis P Curran,

The synthesis of a stereoisomer library of 16 murisolins in individual pure form by fluorous mixture synthesis is reported. Four stereoisomeric precursors are tagged with different fluorous tags, and the resulting mixture is taken through the synthesis with four splits and late stage demixing and detagging to give all 16 products. These products exhibit only six different sets of NMR spectra, but all can be differentiated by chiral HPLC. The structure of murisolin is confirmed, but the structures of murisolin A and 16,19-cis-murisolin may never be known with certainty because insufficient data were collected on natural samples to differentiate each of them from one other isomer.

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers. Publishing Authors By Initials

Q Zhang,H Lu,C Richard,DP Curran,

For similar natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research abstracts see: natural sciences: chemistry: chemistry, organic: isomerism: stereoisomerism research

PUBMED ID PMID:

MEDLINE DATE:

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 36-7

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 14

MONTH: Jan

YEAR: 2004

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers. Keywords Mesh Terms:

KEYWORDS: Stereoisomerism

MESH TERMS: chemistry

Chemical & Substance for Abstract: Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers. Information

Substance Name: Furans

Registry Number: 0

Grant and Affiliation Information for Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers.

AFFILIATION: Department of Chemistry and Center for Combinatorial Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Am Chem Soc

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Fluorous mixture synthesis of stereoisomer libraries: total syntheses of +-murisolin and fifteen diastereoisomers Related Publications

• 'SiCKO'.
• Adolescent chronic pain problems in the school setting: exploring the experiences and beliefs of selected school personnel through focus group methodology.
• Aliskiren: a review of its use in the management of hypertension.
• Amide bond formation with a new fluorous carbodiimide: separation by reverse fluorous solid-phase extraction.
• An evaluation of Merocel and Series 5000 nasal packs in patients following nasal surgery: a prospective randomised trial.
• Are we failing workers with symptoms suggestive of occupational asthma?
• Canada's food and drug regulations.
• Case report of laceration of the liver.
• Cross-task individual differences in error processing: neural, electrophysiological, and genetic components.
• ERP correlates of familiarity and recollection processes in visual associative recognition.
• Effects Of Creatine Supplementation On The Physical Working Capacity At Fatigue Threshold And Muscle Function In Elderly Men And Women (64-86 Years): 2318: Board #231 June 1 9:00 AM -10:30 AM.
• Equine fetal kinetics: Entry and retention of fetal hind limbs in a uterine horn.
• Event-related potentials and recognition memory.
• Fluorous mixture synthesis of stereoisomer libraries: total syntheses of (+)-murisolin and fifteen diastereoisomers.
• Fractal rotation isolates mechanisms for form-dependent motion in human vision.
• Frank v. State of Maryland.
• Imaging response in malignant glioma, RTOG 90-06.
• Intramolecular carbozincation of unactivated alkenes occurs through a zinc radical transfer mechanism.
• Neurocognitive function in current and ex-users of ecstasy in comparison to both matched polydrug-using controls and drug-naïve controls.
• Nitazoxanide : a review of its use in the treatment of gastrointestinal infections.
• Not just a middle-class affliction: crafting a social work research agenda on postpartum depression.
• Perceived need for alcohol, drug, and mental health treatment.
• Peripheral odontogenic tumors.
• Pharmacological manipulations of arousal and memory for emotional material: effects of a single dose of methylphenidate or lorazepam.
• Phase-vanishing reactions that use fluorous media as a phase screen. Facile, controlled bromination of alkenes by dibromine and dealkylation of aromatic ethers by boron tribromide.
• Spotlight on inhaled human insulin (exubera((r))) in diabetes mellitus.
• Straight to the heart. By understanding the heart's anatomy, you can understand cardiac disorders and terminology.
• Studying the effect on system preference by varying coproduct allocation in creating life-cycle inventory.
• Tuberculous mesenteric adenitis.
• Variations in drinking patterns in the rural South: joint effects of race, gender, and rural residence.