Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis.

Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis. Research Abstract Details 

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Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis. Abstract Text:

Charles L Balzli,Clare C McCormick,Armando R Caballero,Bo Huang,Laura Wigington,Emily Smith,Aihua Tang,Richard J O'Callaghan,Charles L Balzli,Clare C McCormick,Armando R Caballero,Bo Huang,Laura Wigington,Emily Smith,Aihua Tang,Richard J O'Callaghan,

PURPOSE: To develop a rabbit model of post-laser in situ keratomileusis (LASIK) methicillin-resistant Staphylococcus aureus (MRSA) keratitis for studying fluoroquinolone prophylaxis and treatment. SETTING: Department of Microbiology, University of Mississippi Medical Center, Jackson, Mississippi, USA. METHODS: An MRSA keratitis isolate (5 muL, 500 colony forming units [CFU]) was inoculated underneath a corneal flap. Bacterial growth and pathology were determined by quantitative cultures (CFU) and slitlamp examination, respectively. The effectiveness of commercial moxifloxacin and gatifloxacin formulations was compared in 3 regimens: prophylaxis (4 drops before inoculation), early therapy (single drop hourly from 4 to 9 hours postinfection), and late therapy (single drop hourly from 10 to 15 hours postinfection). Zones of bacterial inhibition to known in vivo antibiotic concentrations were determined. RESULTS: Bacteria grew to a maximum of approximately 10(6) CFU/cornea within 10 hours postinfection. The slitlamp examination scores showed pathologic changes beginning 10 hours postinfection and progressed throughout the infection. For prophylaxis, eyes treated with moxifloxacin had significantly fewer CFU than gatifloxacin-treated eyes or untreated controls (both P

Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis. Publishing Authors By Initials

CL Balzli,CC McCormick,AR Caballero,B Huang,L Wigington,E Smith,A Tang,RJ O'Callaghan,CL Balzli,CC McCormick,AR Caballero,B Huang,L Wigington,E Smith,A Tang,RJ O'Callaghan,

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Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cataract and refractive surgery

VOLUME: 34

Page Numbers: 295-301

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ISSN: 0886-3350

DAY: 4

MONTH: Feb

YEAR: 2008

Fluoroquinolone therapy in a rabbit model of post-LASIK methicillin-resistant Staphylococcus aureus keratitis. Information

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LANGUAGE: eng

NlmUniqueID: 8604171

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AFFILIATION: From the Department of Microbiology (Balzli, McCormick, Caballero, Tang, O'Callaghan) and the Department of Ophthalmology (Huang, Wigington, Smith), University of Mississippi Medical Center, Jackson, Mississippi, USA.

Country: United States

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MEDLINETA: J Cataract Refract Surg

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