Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors. Research Abstract Details 

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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors. Abstract Text:

Scott D Edmondson,Lan Wei,Jinyou Xu,Jackie Shang,Shiyao Xu,Jianmei Pang,Ashok Chaudhary,Dennis C Dean,Huaibing He,Barbara Leiting,Kathryn A Lyons,Reshma A Patel,Sangita B Patel,Giovanna Scapin,Joseph K Wu,Maria G Beconi,Nancy A Thornberry,Ann E Weber,Scott D Edmondson,Lan Wei,Jinyou Xu,Jackie Shang,Shiyao Xu,Jianmei Pang,Ashok Chaudhary,Dennis C Dean,Huaibing He,Barbara Leiting,Kathryn A Lyons,Reshma A Patel,Sangita B Patel,Giovanna Scapin,Joseph K Wu,Maria G Beconi,Nancy A Thornberry,Ann E Weber,

The synthesis, selectivity, rat pharmacokinetic profile, and drug metabolism profiles of a series of potent fluoroolefin-derived DPP-4 inhibitors (4) are reported. A radiolabeled fluoroolefin 33 was shown to possess a high propensity to form reactive metabolites, thus revealing a potential liability for this class of DPP-4 inhibitors.

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors. Publishing Authors By Initials

SD Edmondson,L Wei,J Xu,J Shang,S Xu,J Pang,A Chaudhary,DC Dean,H He,B Leiting,KA Lyons,RA Patel,SB Patel,G Scapin,JK Wu,MG Beconi,NA Thornberry,AE Weber,SD Edmondson,L Wei,J Xu,J Shang,S Xu,J Pang,A Chaudhary,DC Dean,H He,B Leiting,KA Lyons,RA Patel,SB Patel,G Scapin,JK Wu,MG Beconi,NA Thornberry,AE Weber,

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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 18

Page Numbers: 2409-13

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ISSN: 1464-3405

DAY: 26

MONTH: 02

YEAR: 2008

Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors. Information

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LANGUAGE: eng

NlmUniqueID: 9107377

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Grant and Affiliation Information for Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.

AFFILIATION: Department of Medicinal Chemistry, Merck & Co. Inc., PO Box 2000, Rahway, NJ 07065, USA. scott_edmondson@merck.com

Country: England

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MEDLINETA: Bioorg Med Chem Lett

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