Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety.

Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety. Research Abstract Details 

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Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety. Abstract Text:

Frank Seela,Kuiying Xu,Padmaja Chittepu,Xin Ming,Frank Seela,Kuiying Xu,Padmaja Chittepu,Xin Ming,Frank Seela,Kuiying Xu,Padmaja Chittepu,Xin Ming,Frank Seela,Kuiying Xu,Padmaja Chittepu,Xin Ming,

7-Deaza-7-fluoro-purine 2'-deoxynucleosides as well as 2'-deoxy-2'-fluoroarabinofuranosyl nucleosides 1-8 were synthesized. The fluorine atom was introduced on the base level with Selectfluor. Nucleobase-anion glycosylation was then employed to form the nucleosides. Properties of the fluorine compounds were studied in solution and in solid state. Compound 4a was incorporated into oligonucleotides where the stabilizing effect was observed.

Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety. Publishing Authors By Initials

F Seela,K Xu,P Chittepu,X Ming,F Seela,K Xu,P Chittepu,X Ming,F Seela,K Xu,P Chittepu,X Ming,F Seela,K Xu,P Chittepu,X Ming,

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Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleosides, nucleotides & nucleic acids

VOLUME: 26

Page Numbers: 607-10

Journal Abbreviation: Nucleosides Nucleotides Nuclei

ISSN: 1525-7770

DAY: 10

MONTH: 12

YEAR: 2007

Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety. Information

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LANGUAGE: eng

NlmUniqueID: 100892832

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Grant and Affiliation Information for Fluorinated 7-deazapurine 2'-deoxyribonucleosides: modification at the nucleobase and the sugar moiety.

AFFILIATION: Laboratory of Bioorganic Chemistry and Chemical Biology, Center for Nanotechnology, Münster, Germany.

Country: United States

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MEDLINETA: Nucleosides Nucleotides Nuclei

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