Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study.

Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study. Research Abstract Details 

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Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study. Abstract Text:

Satoshi Utsuki,Norio Miyoshi,Hidehiro Oka,Yoshiteru Miyajima,Satoru Shimizu,Sachio Suzuki,Kiyotaka Fujii,

We performed a pathological study to identify the locus of production of protoporphyrin IX (PPIX) in human metastatic brain tumors. Patients with metastatic brain tumors (n = 11) received 1 g of 5-aminolevulinic acid (5-ALA) perorally 2 h before undergoing surgery. The target region was exposed to laser light with a peak wavelength of 405 +/- 1 nm and an output of 40 mW. Tissue samples from the tumor bulk and surrounding areas were examined by histological and fluorescence methods. Of the 11 tumors, 9 manifested PPIX fluorescence in the tumor bulk and peritumoral brain tissue. Our findings indicate that PPIX fluorescence can be observed in peritumoral edematous areas that are free of neoplastic cells, because PPIX produced by neoplastic cells leaks into the surrounding edematous area.

Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study. Publishing Authors By Initials

S Utsuki,N Miyoshi,H Oka,Y Miyajima,S Shimizu,S Suzuki,K Fujii,

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Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain tumor pathology

VOLUME: 24

Page Numbers: 53-5

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ISSN: 1433-7398

DAY: 28

MONTH: 11

YEAR: 2007

Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study. Information

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LANGUAGE: eng

NlmUniqueID: 9716507

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Grant and Affiliation Information for Fluorescence-guided resection of metastatic brain tumors using a 5-aminolevulinic acid-induced protoporphyrin IX: pathological study.

AFFILIATION: Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa, 228-8555, Japan, utsuki@med.kitasato-u.ac.jp.

Country: Japan

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MEDLINETA: Brain Tumor Pathol

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