Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative.

Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative. Research Abstract Details 

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Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative. Abstract Text:

Kotaro Morita,Yusuke Sato,Takehiro Seino,Seiichi Nishizawa,Norio Teramae,Kotaro Morita,Yusuke Sato,Takehiro Seino,Seiichi Nishizawa,Norio Teramae,Kotaro Morita,Yusuke Sato,Takehiro Seino,Seiichi Nishizawa,Norio Teramae,

A novel hydrogen bond-forming ligand for pyrimidine/purine transversion, which contains both a fluorescent naphthyridine moiety and a ferrocenyl group as an electrochemical indicator, is described. Hydrogen bond-mediated recognition for a target nucleobase at an abasic site in a DNA duplex is confirmed by both fluorescence and electrochemical measurements. The analysis by fluorescence titration reveals that the ligand shows significant fluorescent quenching upon formation of a 1 : 1 complex with the target nucleobase opposite the abasic site, and the selectivity is in the order of cytosine > thymine > adenine, guanine, reflecting the stability of the hydrogen bond formation.

Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative. Publishing Authors By Initials

K Morita,Y Sato,T Seino,S Nishizawa,N Teramae,K Morita,Y Sato,T Seino,S Nishizawa,N Teramae,K Morita,Y Sato,T Seino,S Nishizawa,N Teramae,

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Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic & biomolecular chemistry

VOLUME: 6

Page Numbers: 266-8

Journal Abbreviation: Org. Biomol. Chem.

ISSN: 1477-0520

DAY: 4

MONTH: 12

YEAR: 2007

Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative. Information

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LANGUAGE: eng

NlmUniqueID: 101154995

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Grant and Affiliation Information for Fluorescence and electrochemical detection of pyrimidine/purine transversion by a ferrocenyl aminonaphthyridine derivative.

AFFILIATION: Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan. teramae@mail.tains.tohoku.ac.jp.

Country: England

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MEDLINETA: Org Biomol Chem

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