Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia.

Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia. Research Abstract Details 

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Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia. Abstract Text:

Jing Xue,Xinsheng Bi,Guohao Wu,Dan Meng,Jing Fang,Jing Xue,Xinsheng Bi,Guohao Wu,Dan Meng,Jing Fang,

Fludarabine is the major drug against chronic lymphoblastic leukemia. However, the effects of fludarabine on solid tumors remain unclear. We reported previously that fludarabine inhibited expression of hypoxia-inducible factor 1alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) in human ovarian cancer cells. The present study aims to investigate, (1) the mechanisms that fludarabine inhibits expression of HIF-1alpha and (2) the effects of fludarabine on tumor cells survival under hypoxia. Human hepatoma HepG2 cells were tested. We found that fludarabine reduced HIF-1alpha stability through prolyl hydroxylation. Fludarabine suppressed hypoxia-induced expression of VEGF and its receptor KDR. It inhibited VEGF-induced activation of AKT and ERK signaling and reduced hypoxia-enhanced HepG2 cell survivability. HepG2 cells were much more sensitive to fludarabine treatment under hypoxia than under nomoxia. These results suggest that fludarabine reduces survivability of HepG2 cells via VEGF signaling under hypoxia.

Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia. Publishing Authors By Initials

J Xue,X Bi,G Wu,D Meng,J Fang,J Xue,X Bi,G Wu,D Meng,J Fang,

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Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of biochemistry and biophysics

VOLUME: 468

Page Numbers: 100-6

Journal Abbreviation: Arch. Biochem. Biophys.

ISSN: 1096-0384

DAY: 25

MONTH: 09

YEAR: 2007

Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia. Information

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LANGUAGE: eng

NlmUniqueID: 372430

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Grant and Affiliation Information for Fludarabine reduces survivability of HepG2 cells through VEGF under hypoxia.

AFFILIATION: The Institute for Nutritional Sciences, Shanghai Institute for Biological Sciences, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

Country: United States

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MEDLINETA: Arch Biochem Biophys

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